Oocyte Development and Loss

Abstract

Soon after implantation, cell lineages bifurcate into future somatic and germ cells. Canonical expression of germ cell–specific genes continues during and after their migration to the gonadal ridge, where, after further cell cycles, they enter meiosis, form syncytial clusters, and arrest at diplotene for folliculogenesis. The balance between cell survival and death leaves an ovarian follicular reserve as a legacy.

Keywords

age - follicle - germ cell - oocyte - ovarian reserve

• References

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