Frauenheilkunde up2date, Table of Contents Frauenheilkunde up2date 2014; 8(1): 25-40DOI: 10.1055/s-0033-1357879 Geburtshilfe und Perinatalmedizin Georg Thieme Verlag KG Stuttgart · New York Hepatologische Erkrankungen in der Schwangerschaft Mod. nach Erstpublikation in Gastroenterologie up2date 2013; 9: 25–40 Vincent Zimmer , Frank Lammert Recommend Article Abstract Buy Article All articles of this category Full Text References Literatur 1 Schutt VA, Minuk GY. Liver diseases unique to pregnancy. Best Pract Res Clin Gastroenterol 2007; 21: 771-792 2 Joshi D, James A, Quaglia A et al. Liver disease in pregnancy. Lancet 2010; 375: 594-605 3 Pusl T, Beuers U. Intrahepatic cholestasis of pregnancy. Orphanet J Rare Dis 2007; 2: 26 4 Müllenbach R, Linton KJ, Wiltshire S et al. ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy. J Med Genet 2003; 40: e70 5 Dixon PH, van Mil SW, Chambers J et al. Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy. Gut 2009; 58: 537-544 6 Van Mil SW, Milona A, Dixon PH et al. Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy. Gastroenterology 2007; 133: 507-516 7 Reyes H, Sjovall J. Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy. Ann Med 2000; 32: 94-106 8 Debry P, Nash EA, Neklason DW et al. Role of multidrug resistance P-glycoproteins in cholesterol esterification. J Biol Chem 1997; 272: 1026-1031 9 Zimmer V, Müllenbach R, Simon E et al. Combined functional variants of hepatobiliary transporters and FXR aggravate intrahepatic cholestasis of pregnancy. Liver Int 2009; 29: 1286-1288 10 Ropponen A, Sund R, Riikonen S et al. Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: a population-based study. Hepatology 2006; 43: 723-728 11 Locatelli A, Roncaglia N, Arreghini A et al. Hepatitis C virus infection is associated with a higher incidence of cholestasis of pregnancy. Br J Obstet Gynaecol 1999; 106: 498-500 12 Ziol M, Barbu V, Rosmorduc O et al. ABCB4 heterozygous gene mutations associated with fibrosing cholestatic liver disease in adults. Gastroenterology 2008; 135: 131-141 13 Glantz A, Marschall HU, Mattsson LA. Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates. Hepatology 2004; 40: 467-474 14 EASL. Clinical Practice Guidelines: management of cholestatic liver diseases. J Hepatol 2009; 51: 237-267 15 Bacq Y, Sentilhes L, Reyes HB et al. Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis. Gastroenterology 2012; 143: 1492-1501 16 Chappell LC, Gurung V, Seed PT et al. Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial. Br Med J 2012; 344: e3799 17 Beuers U. Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis. Nat Clin Pract Gastroenterol Hepatol 2006; 3: 318-328 18 Binder T, Salaj P, Zima T et al. Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy. J Perinat Med 2006; 34: 383-391 19 Ibdah JA. Acute fatty liver of pregnancy: an update on pathogenesis and clinical implications. World J Gastroenterol 2006; 12: 7397-7404 20 Ibdah JA. Role of genetic screening in identifying susceptibility to acute fatty liver of pregnancy. Nat Clin Pract Gastroenterol Hepatol 2005; 2: 494-495 21 Van Dyke R. The Liver in Pregnancy. In: Zakim D, Boyer TD, eds. Hepatology. A Textbook of Liver Disease. Philadelphia: Saunders; 2002: 1591-1616 22 Sandhu BS, Sanyal AJ. Pregnancy and liver disease. Gastroenterol Clin North Am 2003; 32: 407-436 ix 23 Abildgaard U, Heimdal K. Pathogenesis of the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP): a review. Eur J Obstet Gynecol Reprod Biol 2013; 166: 117-123 24 Clark EA, Silver RM, Branch DW. Do antiphospholipid antibodies cause preeclampsia and HELLP syndrome?. Curr Rheumatol Rep 2007; 9: 219-225 25 Tallarek AC, Stepan H. Präeklampsie und HELLP-Syndrom als geburtshilfliche Notfälle. Med Klin Intensivmed Notfmed 2012; 107: 96-100 26 Rath W, Fischer T, Klockenbusch W. Diagnostik und Therapie hypertensiver Schwangerschaftserkrankungen. Leitlinie der Arbeitsgemeinschaft Schwangerschaftshochdruck/Gestose der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e.V. (DGGG). AWMF-Leitlinien-Register Nr. 015/018. 2008 letzte Aktualisierung 05/2008. 27 Ismail SK, Kenny L. Review on hyperemesis gravidarum. Best Pract Res Clin Gastroenterol 2007; 21: 755-769 28 Hay JE. Liver disease in pregnancy. Hepatology 2008; 47: 1067-1076 29 Elinav E, Ben-Dov IZ, Shapira Y et al. Acute hepatitis A infection in pregnancy is associated with high rates of gestational complications and preterm labor. Gastroenterology 2006; 130: 1129-1134 30 Kumar A, Beniwal M, Kar P et al. Hepatitis E in pregnancy. Int J Gynaecol Obstet 2004; 85: 240-244 31 Cornberg M, Protzer U, Petersen J et al. Aktualisierung der S3-Leitlinie zur Prophylaxe, Diagnostik und Therapie der Hepatitis-C-Virus(HCV)-Infektion. Z Gastroenterol 2011; 49: 871-930 32 Shepard CW, Simard EP, Finelli L et al. Hepatitis B virus infection: epidemiology and vaccination. Epidemiol Rev 2006; 28: 112-125 33 Wiseman E, Fraser MA, Holden S et al. Perinatal transmission of hepatitis B virus: an Australian experience. Med J Aust 2009; 190: 489-492 34 ter Borg MJ, Leemans WF, de Man RA et al. Exacerbation of chronic hepatitis B infection after delivery. J Viral Hepat 2008; 15: 37-41 35 Han GR, Cao MK, Zhao W et al. A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infection. J Hepatol 2011; 55: 1215-1221 36 Brown Jr RS, Verna EC, Pereira MR et al. Hepatitis B virus and human immunodeficiency virus drugs in pregnancy: findings from the Antiretroviral Pregnancy Registry. J Hepatol 2012; 57: 953-959 37 EASL. Clinical Practice Guidelines: management of hepatitis C virus infection. J Hepatol 2011; 55: 245-264 38 Zanetti AR, Tanzi E, Newell ML. Mother-to-infant transmission of hepatitis C virus. J Hepatol 1999; 31 (Suppl. 01) 96-100 39 Sarrazin C, Berg T, Ross RS et al. Update der S3-Leitlinie zur Prophylaxe, Diagnostik und Therapie der Hepatitis-C-Virus(HCV)-Infektion. Z Gastroenterol 2010; 48: 289-351 40 Conte D, Fraquelli M, Prati D et al. Prevalence and clinical course of chronic hepatitis C virus (HCV) infection and rate of HCV vertical transmission in a cohort of 15, 250 pregnant women. Hepatology 2000; 31: 751-755 41 Schramm C, Herkel J, Beuers U et al. Pregnancy in autoimmune hepatitis: outcome and risk factors. Am J Gastroenterol 2006; 101: 556-560 42 Westbrook RH, Yeoman AD, Kriese S et al. Outcomes of pregnancy in women with autoimmune hepatitis. J Autoimmun 2012; 38: J239-J244 43 Beuers U, Wiedmann KH, Kleber G et al. Therapie der Autoimmunhepatitis, primär biliären Zirrhose und primär sklerosierenden Cholangitis: Konsensus der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten. Z Gastroenterol 1997; 35: 1041-1049 44 Hoffmann JC, Preiss JC, Autschbach F et al. S3-Leitlinie Diagnostik und Therapie des Morbus Crohn. Z Gastroenterol 2008; 46: 1094-1146 45 Lammert F, Rath W. Lebererkrankungen. In: Kainer FK, Hrsg. Facharzt Geburtsmedizin. 2. Auflage. München: Urban & Fischer, Elsevier; 2011: 498-526 46 Ko CW, Beresford SA, Schulte SJ et al. Incidence, natural history, and risk factors for biliary sludge and stones during pregnancy. Hepatology 2005; 41: 359-365 47 Lammert F, Neubrand MW, Bittner R et al. S3-Leitlinie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten und der Deutschen Gesellschaft für Viszeralchirurgie zur Diagnostik und Behandlung von Gallensteinen. Z Gastroenterol 2007; 45: 971-1001 48 Duraiswamy S, Sheffield J, McIntire D et al. The change in etiology of hyperbilirubinemia in pregnancy over the last 35 years. Hepatology 2012; 56: 550A