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Drug Res (Stuttg) 2014; 64(7): 343-347
DOI: 10.1055/s-0033-1358695
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Effect of Diclofenac on the Pharmacokinetics of Moxifloxacin in Rats

L. Chen
1   Department of Pediatrics of Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
,
S. Guo
1   Department of Pediatrics of Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
,
M. Xu
1   Department of Pediatrics of Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
,
L.-X. Wu
1   Department of Pediatrics of Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
,
J.-H. Zhang
1   Department of Pediatrics of Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
› Author Affiliations
Further Information

Publication History

received 23 September 2013

accepted 10 October 2013

Publication Date:
13 November 2013 (online)

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Abstract

A sensitive and specific method was developed and validated for the determination of moxifloxacin in plasma using HPLC. The effect of diclofenac (12.5, 25, 50 mg/kg) on the pharmacokinetics of orally administered moxifloxacin (40 mg/kg) in rats was investigated. Pharmacokinetic parameters of moxifloxacin were determined in rats following oral administration to rats in the presence and absence of diclofenac. The coadministration of the 2 drugs resulted in 10~29.5% decrease of the AUC and a 24.7~34% decrease of t1/2 for moxifloxacin; Tmax for moxifloxacin was 1.41~1.9-fold higher than that after the administration of moxifloxacin alone; Cmax for moxifloxacin decreased by 20.5~49%, as compared to that after the administration of moxifloxacin alone. Consequently, moxifloxacin and diclofenac should be monitored closely for potential drug interactions.

Key words

moxifloxacin - diclofenac - pharmacokinetics - HPLC
 

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