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Am J Perinatol 2014; 31(09): 773-780
DOI: 10.1055/s-0033-1361831
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Renal Development and Neonatal Adaptation

M. Saint-Faust
1   Department of Neonatology, Universitary Hospital, Nice, France
,
F. Boubred
2   Department of Neonatology, Universitary Hospital, La Conception and Aix-Marseille University, Marseille, France
,
U. Simeoni
2   Department of Neonatology, Universitary Hospital, La Conception and Aix-Marseille University, Marseille, France
› Author Affiliations
Further Information

Publication History

07 December 2012

27 September 2013

Publication Date:
12 March 2014 (online)

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Abstract

The structural and functional development of the kidney is responsible for a significant impact on postnatal adaptation to extrauterine life. Prenatal or neonatal impairment of nephrogenesis may carry long term, lifelong consequences in terms of reduced nephron endowment, chronic kidney disease, and cardiovascular risks at adulthood. Intrauterine growth restriction, preterm birth, congenital renal, and urinary tract anomalies are for long widely incriminated. Neonatal administration of nephrotoxic drugs has been associated with short-term acute kidney injury and longer chronic kidney disease. This review attempts at offering a comprehensive understanding of the renal development, the neonatal renal transition to extrauterine life and subsequent maturation phase during early infancy. It also focuses on developmental and maturational changes that impact lifelong renal function and adult health.

Keywords

renal development - neonatal adaptation - intrauterine growth restriction - drugs toxicity
 

  • References

  • 1 Faa G, Gerosa C, Fanni D , et al. Morphogenesis and molecular mechanisms involved in human kidney development. J Cell Physiol 2012; 227 (3) 1257-1268
    CrossrefPubMedGoogle Scholar
  • 2 Gao X, Chen X, Taglienti M, Rumballe B, Little MH, Kreidberg JA. Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa. Development 2005; 132 (24) 5437-5449
    CrossrefPubMedGoogle Scholar
  • 3 Tufro A, Norwood VF, Carey RM, Gomez RA. Vascular endothelial growth factor induces nephrogenesis and vasculogenesis. J Am Soc Nephrol 1999; 10 (10) 2125-2134
    PubMedGoogle Scholar
  • 4 Saxen L. Organogenesis of the kidney. In: Barlow PW, Green PB, White CC, eds. Developmental and Cell Biology Series. Cambrige, CA: Cambrige University Press; 1987
    CrossrefGoogle Scholar
  • 5 Merlet-Bénichou C, Gilbert T, Vilar J, Moreau E, Freund N, Lelièvre-Pégorier M. Nephron number: variability is the rule. Causes and consequences. Lab Invest 1999; 79 (5) 515-527
    PubMedGoogle Scholar
  • 6 Chevalier RL. Developmental renal physiology of the low birth weight pre-term newborn. J Urol 1996; 156 (2 Pt 2) 714-719
    CrossrefPubMedGoogle Scholar
  • 7 Burrow CR. Regulatory molecules in kidney development. Pediatr Nephrol 2000; 14 (3) 240-253
    CrossrefPubMedGoogle Scholar
  • 8 Dinchuk JE, Car BD, Focht RJ , et al. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature 1995; 378 (6555) 406-409
    CrossrefPubMedGoogle Scholar
  • 9 McGrath-Morrow S, Cho C, Molls R , et al. VEGF receptor 2 blockade leads to renal cyst formation in mice. Kidney Int 2006; 69 (10) 1741-1748
    CrossrefPubMedGoogle Scholar
  • 10 Quan A. Fetopathy associated with exposure to angiotensin converting enzyme inhibitors and angiotensin receptor antagonists. Early Hum Dev 2006; 82 (1) 23-28
    CrossrefPubMedGoogle Scholar
  • 11 Brophy PD, Robillard JE. Functional development of the kidney in utero. In: Polin RA, Fox WW, Abman SW, eds. Fetal and neonatal physiology, 3th ed. Philadelphia, PA: W.B. Saunders; 2004: 1229-1239
    CrossrefGoogle Scholar
  • 12 Khan KN, Stanfield KM, Dannenberg A , et al. Cyclooxygenase-2 expression in the developing human kidney. Pediatr Dev Pathol 2001; 4 (5) 461-466
    CrossrefPubMedGoogle Scholar
  • 13 Hoster M. Embryonic epithelial membranes transporters. Am J Physiol 2000; 279: F982-F996
    PubMedGoogle Scholar
  • 14 Nielsen S, Frøkiaer J, Marples D, Kwon TH, Agre P, Knepper MA. Aquaporins in the kidney: from molecules to medicine. Physiol Rev 2002; 82 (1) 205-244
    PubMedGoogle Scholar
  • 15 Solhaug MJ, Jose PA. Postnatal maturation of renal blood flow. In: Polin RA, Fox WW, Abman SW, eds. Fetal and Neonatal Physiology, 3rd ed. Philadephia, PA: W.B. Saunders; 2004: 1243-1249
    Google Scholar
  • 16 Guignard J. Agression et protection du rein immature. In: Médicaments. Néphrotoxicité. Insuffisance rénale chez le nouveau-né, E.SAS, editor. Elsevier SAS; 2001: 85-94
    Google Scholar
  • 17 Guignard JP, Torrado A, Da Cunha O, Gautier E. Glomerular filtration rate in the first three weeks of life. J Pediatr 1975; 87 (2) 268-272
    CrossrefPubMedGoogle Scholar
  • 18 Thayyil S, Sheik S, Kempley ST, Sinha A. A gestation- and postnatal age-based reference chart for assessing renal function in extremely premature infants. J Perinatol 2008; 28 (3) 226-229
    CrossrefPubMedGoogle Scholar
  • 19 Tsampalieros A, Lepage N, Feber J. Intraindividual variability of the modified Schwartz and novel CKiD GFR equations in pediatric renal transplant patients. Pediatr Transplant 2011; 15 (7) 760-765
    CrossrefPubMedGoogle Scholar
  • 20 Hoseini R, Otukesh H, Rahimzadeh N, Hoseini S. Glomerular function in neonates. Iran J Kidney Dis 2012; 6 (3) 166-172
    PubMedGoogle Scholar
  • 21 Armangil D, Yurdakök M, Canpolat FE, Korkmaz A, Yiğit S, Tekinalp G. Determination of reference values for plasma cystatin C and comparison with creatinine in premature infants. Pediatr Nephrol 2008; 23 (11) 2081-2083
    CrossrefPubMedGoogle Scholar
  • 22 Gallini F, Maggio L, Romagnoli C, Marrocco G, Tortorolo G. Progression of renal function in preterm neonates with gestational age < or = 32 weeks. Pediatr Nephrol 2000; 15 (1-2) 119-124
    CrossrefPubMedGoogle Scholar
  • 23 Madsen K, Tinning AR, Marcussen N, Jensen BL. Postnatal development of the renal medulla; role of the reninangiotensin system. Acta Physiol (Oxf) 2013; 208 (1) 41-49
    CrossrefPubMedGoogle Scholar
  • 24 Boubred F, Vendemmia M, Garcia-Meric P, Buffat C, Millet V, Simeoni U. Effects of maternally administered drugs on the fetal and neonatal kidney. Drug Saf 2006; 29 (5) 397-419
    CrossrefPubMedGoogle Scholar
  • 25 Cattarelli D, Chirico G, Simeoni U. Renal effects of antenatally or postnatally administered steroids. Pediatr Med Chir 2002; 24 (2) 157-162
    PubMedGoogle Scholar
  • 26 Tendron A, Decramer S, Justrabo E, Gouyon JB, Semama DS, Gilbert T. Cyclosporin A administration during pregnancy induces a permanent nephron deficit in young rabbits. J Am Soc Nephrol 2003; 14 (12) 3188-3196
    CrossrefPubMedGoogle Scholar
  • 27 Cochat P, Decramer S, Robert-Gnansia E, Dubourg L, Audra P. Renal outcome of children exposed to cyclosporine in utero. Transplant Proc 2004; 36 (2, Suppl) 208S-210S
    CrossrefPubMedGoogle Scholar
  • 28 Drukker A, Guignard JP. Renal aspects of the term and preterm infant: a selective update. Curr Opin Pediatr 2002; 14 (2) 175-182
    CrossrefPubMedGoogle Scholar
  • 29 Rodríguez MM, Gómez AH, Abitbol CL, Chandar JJ, Duara S, Zilleruelo GE. Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatr Dev Pathol 2004; 7 (1) 17-25
    PubMedGoogle Scholar
  • 30 Ligi I, Boubred F, Grandvuillemin I, Simeoni U. The neonatal kidney: implications for drug metabolism and elimination. Curr Drug Metab 2013; 14 (2) 174-177
    PubMedGoogle Scholar
  • 31 Giniger RP, Buffat C, Millet V, Simeoni U. Renal effects of ibuprofen for the treatment of patent ductus arteriosus in premature infants. J Matern Fetal Neonatal Med 2007; 20 (4) 275-283
    CrossrefPubMedGoogle Scholar
  • 32 Cuzzolin L, Fanos V, Pinna B , et al. Postnatal renal function in preterm newborns: a role of diseases, drugs and therapeutic interventions. Pediatr Nephrol 2006; 21 (7) 931-938
    CrossrefPubMedGoogle Scholar
  • 33 Sweet D, Bevilacqua G, Carnielli V , et al; Working Group on Prematurity of the World Association of Perinatal Medicine; European Association of Perinatal Medicine. European consensus guidelines on the management of neonatal respiratory distress syndrome. J Perinat Med 2007; 35 (3) 175-186
    CrossrefPubMedGoogle Scholar
  • 34 Brenner BM, Garcia DL, Anderson S. Glomeruli and blood pressure. Less of one, more the other?. Am J Hypertens 1988; 1 (4 Pt 1) 335-347
    CrossrefPubMedGoogle Scholar
  • 35 Luyckx VA, Brenner BM. The clinical importance of nephron mass. J Am Soc Nephrol 2010; 21 (6) 898-910
    CrossrefPubMedGoogle Scholar
  • 36 Keller G, Zimmer G, Mall G, Ritz E, Amann K. Nephron number in patients with primary hypertension. N Engl J Med 2003; 348 (2) 101-108
    CrossrefPubMedGoogle Scholar
  • 37 Puddu M, Fanos V, Podda F, Zaffanello M. The kidney from prenatal to adult life: perinatal programming and reduction of number of nephrons during development. Am J Nephrol 2009; 30 (2) 162-170
    CrossrefPubMedGoogle Scholar