Erkrankungen des Mittelohres im Kindesalter

A. Minovi; S. Dazert

doi:10.1055/s-0033-1363213

Laryngo-Rhino-Otologie, Inhaltsverzeichnis

Laryngorhinootologie 2014; 93(S 01): S1-S23
DOI: 10.1055/s-0033-1363213

Referat

Erkrankungen des Mittelohres im Kindesalter

Diseases of the Middle Ear in Childhood

A. Minovi

¹Klinik für Hals- Nasen- Ohrenheilkunde Bochum, Kopf- und Halschirurgie der Ruhr Universität Bochum, (Direktor: Prof. Dr. med. S. Dazert)

,

S. Dazert

¹Klinik für Hals- Nasen- Ohrenheilkunde Bochum, Kopf- und Halschirurgie der Ruhr Universität Bochum, (Direktor: Prof. Dr. med. S. Dazert)

› Institutsangaben

Abstract

Zusammenfassung

Erkrankungen des Mittelohres im Kindesalter spielen in der HNO-Heilkunde aufgrund ihrer hohen Inzidenz eine bedeutende Rolle. Einige dieser Krankheiten wie die akute Otitis media oder der chronische Paukenerguss, wurden in den letzten Jahren insbesondere hinsichtlich ihrer soziökonomischer Bedeutung intensiv erforscht. Im folgenden Artikel werden ausgewählte wichtige Krankheiten des Mittelohres vorgestellt, deren Behandlungen einschließlich des Komplikationsmanagements beschrieben und die Ergebnisse anhand der aktuellen Literatur diskutiert werden. Ein zweiter Schwerpunkt dieser Arbeit befasst sich mit aktuellen Möglichkeiten der operativen Hörrehabilitation im Kindesalter. Das knochenverankerte Hörgerät BAHA^® und das aktive, teilimplantierbare Hörsystem Vibrant Soundbridge^® konnten in den letzten Jahren für diese Altersgruppe erfolgreich angewandt werden. Diesbezüglich wird der aktuelle Stand der Literatur im Hinblick auf die klinischen Ergebnisse dieser Hörsysteme erörtert.

Abstract

Diseases of the Middle Ear in Childhood

Middle ear diseases in childhood play an important role in daily ENT practice due to their high incidence. Some of these like acute otitis media or otitis media with effusion have been studied extensively within the last decades. In this article, we present a selection of important childhood middle ear diseases and discuss the actual literature concerning their treatment, management of complications and outcome. Another main topic of this paper deals with the possibilities of surgical hearing rehabilitation in childhood. The bone-anchored hearing aid BAHA^® and the active partially implantable device Vibrant Soundbridge^® could successfully be applied for children. In this manuscript, we discuss the actual literature concerning clinical outcomes of these implantable hearing aids.

Schlüsselwörter

Kinder - Otitis media - Mastoiditis - Cholesteatom - implantierbare Hörsysteme

Key words

children - otitis media - mastoiditis - cholesteatom - implantable hearing aids

Volltext

Referenzen

Literatur
1 Dhooge IJ. Acute Otitis Media in Children. In: Graham JM, Scadding GK, Bull PD. eds. Pediatric ENT. Heidelberg: Springer; 2007: 399-420
2 Strutz J, Mann W. Praxis der HNO-Heilkunde, Kopf- und Halschirurgie. Stuttgart: Thieme; 2009
3 Koneczny N, Schmidt-Troschke S, Berger T et al. Akute Otitis media (AOM) bei Kindern (ICD: H66.0): eine evidenzbasierte Leitlinie – Neue Perspektiven für Kinderärzte in Deutschland. Klin Padiatr 2004; 216: 215-224
4 Wald ER. Acute otitis media and acute bacterial sinusitis. Clin Infect Dis 2011; 52 (Suppl. 04) S277-S283
5 Teele DW, Klein JO, Rosner B. Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study. J Infect Dis 1989; 160: 83-94
6 Vergison A, Dagan R, Arguedas A et al. Otitis media and its consequences: beyond the earache. Lancet Infect Dis 2010; 10: 195-203
7 Monasta L, Ronfani L, Marchetti F et al. Burden of disease caused by otitis media: systematic review and global estimates. PLoS One 2012; 7: e36226
8 Daly KA, Brown JE, Lindgren BR et al. Epidemiology of otitis media onset by six months of age. Pediatrics 1999; 103: 1158-1166
9 Heavner SB, Hardy SM, White DR, Prazma J, Pillsbury 3rd HC. Transient inflammation and dysfunction of the eustachian tube secondary to multiple exposures of simulated gastroesophageal refluxant. Ann Otol Rhinol Laryngol 2001; 110: 928-934
10 Leach AJ, Morris PS. Perspectives on infective ear disease in indigenous Australian children. J Paediatr Child Health 2001; 37: 529-530
11 Niemela M, Pihakari O, Pokka T, Uhari M. Pacifier as a risk factor for acute otitis media: A randomized, controlled trial of parental counseling. Pediatrics 2000; 106: 483-488
12 Ramakrishnan K, Sparks RA, Berryhill WE. Diagnosis and treatment of otitis media. Am Fam Physician 2007; 76: 1650-1658
13 Uhari M, Mantysaari K, Niemela M. A meta-analytic review of the risk factors for acute otitis media. Clin Infect Dis 1996; 22: 1079-1083
14 Coker TR, Chan LS, Newberry SJ et al. Diagnosis, microbial epidemiology, and antibiotic treatment of acute otitis media in children: a systematic review. Jama 2010; 304: 2161-2169
15 Healy GB, Rosbe KW. Otitis Media and Middle Ear Effusions. In: Snow Jr JB, Ballenger JJ. eds. Ballenger’s Otorhinolaryngology Head and Neck Surgery. Hamilton: BC Decker; 2003: 249-260
16 Lieberthal AS, Carroll AE, Chonmaitree T et al. The diagnosis and management of acute otitis media. Pediatrics 2013; 131: e964-e999
17 Heikkinen T, Thint M, Chonmaitree T. Prevalence of various respiratory viruses in the middle ear during acute otitis media. N Engl J Med 1999; 340: 260-264
18 Turner D, Leibovitz E, Aran A et al. Acute otitis media in infants younger than two months of age: microbiology, clinical presentation and therapeutic approach. Pediatr Infect Dis J 2002; 21: 669-674
19 Casey JR, Pichichero ME. Changes in frequency and pathogens causing acute otitis media in 1995–2003. Pediatr Infect Dis J 2004; 23: 824-828
20 Arrieta A, Singh J. Management of recurrent and persistent acute otitis media: new options with familiar antibiotics. Pediatr Infect Dis J 2004; 23: S115-S124
21 Hendley JO. Clinical practice. Otitis media. N Engl J Med 2002; 347: 1169-1174
22 Rovers MM, Schilder AG, Zielhuis GA, Rosenfeld RM. Otitis media. Lancet 2004; 363: 465-473
23 McCormick DP, Saeed K, Uchida T et al. Middle ear fluid histamine and leukotriene B4 in acute otitis media: effect of antihistamine or corticosteroid treatment. International journal of pediatric otorhinolaryngology 2003; 67: 221-230
24 Flynn CA, Griffin GH, Schultz JK. Decongestants and antihistamines for acute otitis media in children. Cochrane Database Syst Rev 2004; CD001727
25 Van Zuijlen DA, Schilder AG, Van Balen FA, Hoes AW. National differences in incidence of acute mastoiditis: relationship to prescribing patterns of antibiotics for acute otitis media?. Pediatr Infect Dis J 2001; 20: 140-144
26 Groth A, Enoksson F, Hermansson A et al. Acute mastoiditis in children in Sweden 1993–2007 – no increase after new guidelines. Int J Pediatr Otorhinolaryngol 2011; 75: 1496-1501
27 Little P, Gould C, Williamson I et al. Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media. BMJ 2001; 322: 336-342
28 Spiro DM, Tay KY, Arnold DH et al. Wait-and-see prescription for the treatment of acute otitis media: a randomized controlled trial. Jama 2006; 296: 1235-1241
29 van Buchem FL, Peeters MF, van’t Hof MA. Acute otitis media: a new treatment strategy. Br Med J (Clin Res Ed) 1985; 290: 1033-1037
30 Rovers MM, Glasziou P, Appelman CL et al. Antibiotics for acute otitis media: a meta-analysis with individual patient data. Lancet 2006; 368: 1429-1435
31 Hoberman A, Paradise JL, Rockette HE et al. Treatment of acute otitis media in children under 2 years of age. N Engl J Med 2011; 364: 105-115
32 Amrhein P, Hospach A, Sittel C, Koitschev A. Akute Otitis media bei Kindern: Antibiose oder „watchful waiting“?. HNO 2013; 61: 374-379
33 DGHNO . Leitlinien der Deutschen Gesellschaft für HNO-Heilkunde Kopf-und Hals-Chirurgie. Antibiotikatherapie der Infektionen an Kopf und Hals. AWMF-Register Nr 01/066 2008
34 Paradise JL. Short-course antimicrobial treatment for acute otitis media: not best for infants and young children. Jama 1997; 278: 1640-1642
35 Piglansky L, Leibovitz E, Raiz S et al. Bacteriologic and clinical efficacy of high dose amoxicillin for therapy of acute otitis media in children. Pediatr Infect Dis J 2003; 22: 405-413
36 Dagan R, Hoberman A, Johnson C et al. Bacteriologic and clinical efficacy of high dose amoxicillin/clavulanate in children with acute otitis media. Pediatr Infect Dis J 2001; 20: 829-837
37 Rubin LG. Prevention and treatment of meningitis and acute otitis media in children with cochlear implants. Otol Neurotol 2010; 31: 1331-1333
38 Fickweiler U, Muller H, Dietz A. Die akute Mastoiditis heute. HNO 2007; 55: 73-80 quiz 81
39 Spratley J, Silveira H, Alvarez I, Pais-Clemente M. Acute mastoiditis in children: review of the current status. Int J Pediatr Otorhinolaryngol 2000; 56: 33-40
40 Benito MB, Gorricho BP. Acute mastoiditis: increase in the incidence and complications. Int J Pediatr Otorhinolaryngol 2007; 71: 1007-1011
41 Kangsanarak J, Navacharoen N, Fooanant S, Ruckphaopunt K. Intracranial complications of suppurative otitis media: 13 years’ experience. Am J Otol 1995; 16: 104-109
42 Prellner K, Rydell R. Acute mastoiditis. Influence of antibiotic treatment on the bacterial spectrum. Acta Otolaryngol 1986; 102: 52-56
43 Geva A, Oestreicher-Kedem Y, Fishman G, Landsberg R, DeRowe A. Conservative management of acute mastoiditis in children. Int J Pediatr Otorhinolaryngol 2008; 72: 629-634
44 Groth A, Enoksson F, Hultcrantz M et al. Acute mastoiditis in children aged 0–16 years – a national study of 678 cases in Sweden comparing different age groups. Int J Pediatr Otorhinolaryngol 2012; 76: 1494-1500
45 Vassbotn FS, Klausen OG, Lind O, Moller P. Acute mastoiditis in a Norwegian population: a 20 year retrospective study. International journal of pediatric otorhinolaryngology 2002; 62: 237-242
46 Nussinovitch M, Yoeli R, Elishkevitz K, Varsano I. Acute mastoiditis in children: epidemiologic, clinical, microbiologic, and therapeutic aspects over past years. Clin Pediatr (Phila) 2004; 43: 261-267
47 Palma S, Fiumana E, Borgonzoni M et al. Acute mastoiditis in children: the “Ferrara” experience. International journal of pediatric otorhinolaryngology 2007; 71: 1663-1669
48 Hoppe JE, Koster S, Bootz F, Niethammer D. Acute mastoiditis – relevant once again. Infection 1994; 22: 178-182
49 Harley EH, Sdralis T, Berkowitz RG. Acute mastoiditis in children: a 12-year retrospective study. Otolaryngol Head Neck Surg 1997; 116: 26-30
50 Bakhos D, Trijolet JP, Moriniere S et al. Conservative management of acute mastoiditis in children. Arch Otolaryngol Head Neck Surg 2011; 137: 346-350
51 Oestreicher-Kedem Y, Raveh E, Kornreich L et al. Complications of mastoiditis in children at the onset of a new millennium. Ann Otol Rhinol Laryngol 2005; 114: 147-152
52 Pang LH, Barakate MS, Havas TE. Mastoiditis in a paediatric population: a review of 11 years experience in management. International journal of pediatric otorhinolaryngology 2009; 73: 1520-1524
53 Mross-Adam C, Klemm E. Die akute Mastoiditis im Kindesalter, eine Analyse des eigenen Krankengutes über 25 Jahre. Laryngorhinootologie 2005; 84: 497-502
54 Arts HA, Neely JG. Intratemporal and intracranial complications of otitis media. In: Bailey BJ. ed. Head and neck surgery – otolaryngology. Philadelphia: Lippincott Williams & Wilkins; 2001: 1759-1772
55 Psarommatis IM, Voudouris C, Douros K et al. Algorithmic management of pediatric acute mastoiditis. Int J Pediatr Otorhinolaryngol 2012; 76: 791-796
56 Vazquez E, Castellote A, Piqueras J et al. Imaging of complications of acute mastoiditis in children. Radiographics 2003; 23: 359-372
57 Luntz M, Brodsky A, Nusem S et al. Acute mastoiditis – the antibiotic era: a multicenter study. Int J Pediatr Otorhinolaryngol 2001; 57: 1-9
58 Helms J. Sanierende und rekonstruktive Operationen an Gehörgang, Mittelohr und Felsenbein. In: Helms J, Jahrsdoerfer RA. eds. Kopf- und Halschirurgie. Stuttgart: Thieme; 1997: 67-130
59 Tos M. Manual of Middle Ear Surgery. Volume 2: Mastoid Surgery and Recosntructive Procedures. Stuttgart: Thieme; 1995
60 Quesnel S, Nguyen M, Pierrot S et al. Acute mastoiditis in children: a retrospective study of 188 patients. Int J Pediatr Otorhinolaryngol 2010; 74: 1388-1392
61 Go C, Bernstein JM, de Jong AL, Sulek M, Friedman EM. Intracranial complications of acute mastoiditis. Int J Pediatr Otorhinolaryngol 2000; 52: 143-148
62 Zanetti D, Nassif N. Indications for surgery in acute mastoiditis and their complications in children. Int J Pediatr Otorhinolaryngol 2006; 70: 1175-1182
63 Lutter SA, Kerschner JE, Chusid MJ. Gradenigo syndrome: a rare but serious complication of otitis media. Pediatr Emerg Care 2005; 21: 384-386
64 Pellegrini S, Gonzalez Macchi ME, Sommerfleck PA, Bernaldez PC. Intratemporal complications from acute otitis media in children: 17 cases in two years. Acta Otorrinolaringol Esp 2012; 63: 21-25
65 Hildmann H, Sudhoff H, Jahnke K. Principles of Individualized Approach to Cholesteatoma Surgery. In: Jahnke K. ed. Current Topics in Otolaryngology – Head and Neck Surgery Middle Ear Surgery Recent Advances and Future Directions. Stuttgart: Thieme; 2004: 73-93
66 Robb PJ. Otitis Media With Effusion. In: Graham JM, Scadding GK, Bull PD. eds. Pediatric ENT. Heidelberg: Springer; 2007: 413-420
67 Zielhuis GA, Rach GH, van den Broek P. Screening for otitis media with effusion in preschool children. Lancet 1989; 1: 311-314
68 Schilder AG, Zielhuis GA, Van Den Broek P. The otological profile of a cohort of Dutch 7.5–8-year-olds. Clin Otolaryngol Allied Sci 1993; 18: 48-54
69 Politzer A. Diagnose und Theraphaie der AnsammIung seroeser Fluessigkeit in der Thrommelhoehle. Wien Med Wochenschr 1867; 17: 224-247
70 Sade J, Eliezer N. Secretory otitis media and the nature of the mucociliary system. Acta Otolaryngol 1970; 70: 351-357
71 Hoffman HJ, Daly KA, Bainbridge KE et al. Panel 1: Epidemiology, natural history, and risk factors. Otolaryngol Head Neck Surg 2013; 148: E1-E25
72 Rosenfeld RM, Kay D. Natural history of untreated otitis media. Laryngoscope 2003; 113: 1645-1657
73 Campbell RG, Birman CS, Morgan L. Management of otitis media with effusion in children with primary ciliary dyskinesia: a literature review. International journal of pediatric otorhinolaryngology 2009; 73: 1630-1638
74 Flynn T, Moller C, Jonsson R, Lohmander A. The high prevalence of otitis media with effusion in children with cleft lip and palate as compared to children without clefts. International journal of pediatric otorhinolaryngology 2009; 73: 1441-1446
75 Schonweiler R, Schonweiler B, Schmelzeisen R. Hörvermögen und Sprachleistungen bei 417 Kindern mit Spaltfehlbildungen. HNO 1994; 42: 691-696
76 Pruliere-Escabasse V, Coste A, Chauvin P et al. Otologic features in children with primary ciliary dyskinesia. Arch Otolaryngol Head Neck Surg 2010; 136: 1121-1126
77 Bernstein JM. Immunologic reactivity in the middle ear in otitis media with effusion. Otolaryngologic Clinics of North America 1991; 24: 845-858
78 Bernstein JM, Doyle WJ. Role of IgE-mediated hypersensitivity in otitis media with effusion: pathophysiologic considerations. Ann Otol Rhinol Laryngol Suppl 1994; 163: 15-19
79 Daniel M, Imtiaz-Umer S, Fergie N, Birchall JP, Bayston R. Bacterial involvement in otitis media with effusion. International journal of pediatric otorhinolaryngology 2012; 76: 1416-1422
80 Post JC, Preston RA, Aul JJ et al. Molecular analysis of bacterial pathogens in otitis media with effusion. Jama 1995; 273: 1598-1604
81 Golz A, Angel-Yeger B, Parush S. Evaluation of balance disturbances in children with middle ear effusion. International journal of pediatric otorhinolaryngology 1998; 43: 21-26
82 Haapaniemi JJ. Pure-tone audiometric and impedance measurements in school-aged children in Finland. Eur Arch Otorhinolaryngol 1997; 254: 269-273
83 Mitchell DB, Ford GR, Albert D, Waldron J. Acoustic reflectometry as an aid to the diagnosis of glue ear. Br J Clin Pract 1990; 44: 557-559
84 Vaughan-Jones R, Mills RP. The Welch Allyn Audioscope and Microtymp: their accuracy and that of pneumatic otoscopy, tympanometry and pure tone audiometry as predictors of otitis media with effusion. J Laryngol Otol 1992; 106: 600-602
85 NHS-Guidelines . National Collaborating Centre for Women’s and Children’s Health. Surgical management of otitis media with effusion in children. London: RCOG Press; 2008
86 Sassen ML, van Aarem A, Grote JJ. Validity of tympanometry in the diagnosis of middle ear effusion. Clin Otolaryngol Allied Sci 1994; 19: 185-189
87 Watters GW, Jones JE, Freeland AP. The predictive value of tympanometry in the diagnosis of middle ear effusion. Clin Otolaryngol Allied Sci 1997; 22: 343-345
88 American Academy of Family Physicians, American Academy of Otolaryngology-Head and Neck Surgery and American Academy of Pediatrics . Subcommittee on Otitis Media With Effusion. Otitis media with effusion. Pediatrics 2004; 113: 1412-1429
89 Rosenfeld RM, Post JC. Meta-analysis of antibiotics for the treatment of otitis media with effusion. Otolaryngol Head Neck Surg 1992; 106: 378-386
90 Williams RL, Chalmers TC, Stange KC, Chalmers FT, Bowlin SJ. Use of antibiotics in preventing recurrent acute otitis media and in treating otitis media with effusion. A meta-analytic attempt to resolve the brouhaha. Jama 1993; 270: 1344-1351
91 Mandel EM, Rockette HE, Bluestone CD, Paradise JL, Nozza RJ. Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. Results of a double-blind, randomized trial. N Engl J Med 1987; 316: 432-437
92 van Zon A, van der Heijden GJ, van Dongen TM, Burton MJ, Schilder AG. Antibiotics for otitis media with effusion in children. Cochrane Database Syst Rev 2012; 9: CD009163
93 Butler CC, Van Der Voort JH. Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children. Cochrane Database Syst Rev 2002; CD001935
94 Hammaren-Malmi S, Saxen H, Tarkkanen J, Mattila PS. Adenoidectomy does not significantly reduce the incidence of otitis media in conjunction with the insertion of tympanostomy tubes in children who are younger than 4 years: a randomized trial. Pediatrics 2005; 116: 185-189
95 Atkinson M. Surgical management of otitis media with effusion in children – NICE guideline: what paediatricians need to know. Arch Dis Child Educ Pract Ed 2009; 94: 115-117
96 Casselbrant ML, Mandel EM, Rockette HE et al. Adenoidectomy for otitis media with effusion in 2–3-year-old children. International journal of pediatric otorhinolaryngology 2009; 73: 1718-1724
97 Popova D, Varbanova S, Popov TM. Comparison between myringotomy and tympanostomy tubes in combination with adenoidectomy in 3–7-year-old children with otitis media with effusion. International journal of pediatric otorhinolaryngology 2010; 74: 777-780
98 van den Aardweg MT, Schilder AG, Herkert E, Boonacker CW, Rovers MM. Adenoidectomy for otitis media in children. Cochrane Database Syst Rev 2010; CD007810
99 MRC Multicentre Otitis Media Study Group . Adjuvant adenoidectomy in persistent bilateral otitis media with effusion: hearing and revision surgery outcomes through 2 years in the TARGET randomised trial. Clin Otolaryngol 2012; 37: 107-116
100 Browning GG, Rovers MM, Williamson I, Lous J, Burton MJ. Grommets (ventilation tubes) for hearing loss associated with otitis media with effusion in children. Cochrane Database Syst Rev 2010; CD001801
101 Diacova S, McDonald TJ. A comparison of outcomes following tympanostomy tube placement or conservative measures for management of otitis media with effusion. Ear Nose Throat J 2007; 86: 552-554
102 Dunne AA, Werner JA. Stand der kontroversen Diskussion um die Pathogenese und Behandlung des chronischen Paukenergusses im Kindesalter. Laryngo-rhino-otologie 2001; 80: 1-10
103 Vlastarakos PV, Nikolopoulos TP, Korres S et al. Grommets in otitis media with effusion: the most frequent operation in children. But is it associated with significant complications?. Eur J Pediatr 2007; 166: 385-391
104 Koopman JP, Reuchlin AG, Kummer EE et al. Laser myringotomy versus ventilation tubes in children with otitis media with effusion: a randomized trial. Laryngoscope 2004; 114: 844-849
105 Berkman ND, Wallace IF, Steiner MJ et al. In: Otitis Media With Effusion: Comparative Effectiveness of Treatments. Rockville (MD): 2013
106 DGHNO. Leilinien der Deutschen Gesellschaft für HNO-Heilkunde Kopf-und Hals-Chirurgie. Leitlinie Seromukotympanum. AWMF-Register Nr 017/004 2011
107 Gunasekera H, Morris PS, McIntyre P, Craig JC. Management of children with otitis media: a summary of evidence from recent systematic reviews. J Paediatr Child Health 2009; 45: 554-562 quiz 562–563
108 Ingels K, Rovers MM, van der Wilt GJ, Zielhuis GA. Ventilation tubes in infants increase the risk of otorrhoea and antibiotic usage. B-Ent 2005; 1: 173-176
109 Hamilton J. Chronic Otitis media. In: Graham JM, Scadding GK, Bull PD. eds. Pediatric ENT. Heidelberg: Springer; 2007: 421-440
110 WHO . Chronic suppurative otitis media. Burden of Illness and Management Options. Genf: WHO; 2004
111 Marchisio P, Chonmaitree T, Leibovitz E et al. Panel 7: Treatment and comparative effectiveness research. Otolaryngol Head Neck Surg 2013; 148: E102-E121
112 Gates GA, Klein JO, Lim DJ et al. Recent advances in otitis media. 1. Definitions, terminology, and classification of otitis media. Ann Otol Rhinol Laryngol Suppl 2002; 188: 8-18
113 Telian SA, Schmalbach CE. Chronic Otitis Media. In: Snow Jr JB, Ballenger JJ. eds. Ballenger’s Otorhinolaryngology Head and Neck Surgery. Hamilton: BC Decker; 2003: 261-293
114 Fliss DM, Shoham I, Leiberman A, Dagan R. Chronic suppurative otitis media without cholesteatoma in children in southern Israel: incidence and risk factors. Pediatr Infect Dis J 1991; 10: 895-899
115 Verhoeff M, van der Veen EL, Rovers MM, Sanders EA, Schilder AG. Chronic suppurative otitis media: a review. International journal of pediatric otorhinolaryngology 2006; 70: 1-12
116 Bluestone CD. Pathogenesis of otitis media: role of eustachian tube. Pediatr Infect Dis J 1996; 15: 281-291
117 Nelson JD. Chronic suppurative otitis media. Pediatr Infect Dis J 1988; 7: 446-448
118 Atef A, Ayad EE. Ciliary count in chronic suppurative otitis media: comparative quantitative study between mucosal and squamous types using scanning electron microscopy and image analysis. J Laryngol Otol 2004; 118: 343-347
119 Kaplan DM, Fliss DM, Kraus M, Dagan R, Leiberman A. Audiometric findings in children with chronic suppurative otitis media without cholesteatoma. International journal of pediatric otorhinolaryngology 1996; 35: 89-96
120 Cureoglu S, Schachern PA, Paparella MM, Lindgren BR. Cochlear changes in chronic otitis media. Laryngoscope 2004; 114: 622-626
121 Macfadyen CA, Acuin JM, Gamble C. Topical antibiotics without steroids for chronically discharging ears with underlying eardrum perforations. The Cochrane database of systematic reviews 2005; CD004618
122 Vrabec JT, Deskin RW, Grady JJ. Meta-analysis of pediatric tympanoplasty. Arch Otolaryngol Head Neck Surg 1999; 125: 530-534
123 James AL, Papsin BC. Ten top considerations in pediatric tympanoplasty. Otolaryngol Head Neck Surg 2012; 147: 992-998
124 Yung M, Neumann C, Vowler SL. A longitudinal study on pediatric myringoplasty. Otol Neurotol 2007; 28: 353-355
125 Boronat-Echeverria NE, Reyes-Garcia E, Sevilla-Delgado Y, Aguirre-Mariscal H, Mejia-Arangure JM. Prognostic factors of successful tympanoplasty in pediatric patients: a cohort study. BMC Pediatr 2012; 12: 67
126 Gurr A, Sudhoff H, Hildmann H. Approaches to the Middle Ear. In: Hildmann H, Sudhoff H. eds. Middle Ear Surgery. Heidelberg: Springer; 2011: 19-23
127 Sanna M, Sunose H, Mancini F, Russo A, Taibah A. Middle Ear and Mastoid Microsurgery. Stuttgart: Thieme; 2003
128 Sarkar S, Roychoudhury A, Roychaudhuri BK. Tympanoplasty in children. Eur Arch Otorhinolaryngol 2009; 266: 627-633
129 Singh GB, Sidhu TS, Sharma A, Singh N. Tympanoplasty type I in children – an evaluative study. International journal of pediatric otorhinolaryngology 2005; 69: 1071-1076
130 Uyar Y, Keles B, Koc S, Ozturk K, Arbag H. Tympanoplasty in pediatric patients. International journal of pediatric otorhinolaryngology 2006; 70: 1805-1809
131 Zahnert T. Gestörtes Hören. Chirurgische Verfahren. Laryngorhinootologie 2005; 84 (Suppl. 01) S37-S50
132 Dornhoffer JL. Cartilage Tympanoplasty. Otolaryngologic Clinics of North America 2006; 39: 1161-1176
133 Heermann Jr J, Heermann H, Kopstein E. Fascia and cartilage palisade tympanoplasty. Nine years’ experience. Arch Otolaryngol 1970; 91: 228-241
134 Neumann A, Schultz-Coulon HJ, Jahnke K. Type III tympanoplasty applying the palisade cartilage technique: a study of 61 cases. Otol Neurotol 2003; 24: 33-37
135 Carr MM, Poje CP, Nagy ML, Pizzuto MP, Brodsky LS. Success rates in paediatric tympanoplasty. J Otolaryngol 2001; 30: 199-202
136 Umapathy N, Dekker PJ. Myringoplasty: is it worth performing in children?. Arch Otolaryngol Head Neck Surg 2003; 129: 1053-1055
137 Friedman AB, Gluth MB, Moore PC, Dornhoffer JL. Outcomes of Cartilage Tympanoplasty in the Pediatric Population. Otolaryngol Head Neck Surg 2013; 148: 297-301
138 Ozbek C, Ciftci O, Tuna EE, Yazkan O, Ozdem C. A comparison of cartilage palisades and fascia in type 1 tympanoplasty in children: anatomic and functional results. Otol Neurotol 2008; 29: 679-683
139 Merenda D, Koike K, Shafiei M, Ramadan H. Tympanometric volume: a predictor of success of tympanoplasty in children. Otolaryngol Head Neck Surg 2007; 136: 189-192
140 Emir H, Ceylan K, Kizilkaya Z et al. Success is a matter of experience: type 1 tympanoplasty: influencing factors on type 1 tympanoplasty. Eur Arch Otorhinolaryngol 2007; 264: 595-599
141 Tos M, Poulsen G. Attic retractions following secretory otitis. Acta Otolaryngol 1980; 89: 479-486
142 Cassano M, Cassano P. Retraction pockets of pars tensa in pediatric patients: clinical evolution and treatment. International journal of pediatric otorhinolaryngology 2010; 74: 178-182
143 Neumann A, Dazert S. Empfehlungen zur Behandlung von Trommelfell-Retraktionstaschen. Laryngorhinootologie 2007; 86: 92-94
144 Kakehata S, Hozawa K, Futai K, Shinkawa H. Evaluation of attic retraction pockets by microendoscopy. Otol Neurotol 2005; 26: 834-837
145 Couloigner V, Molony N, Viala P et al. Cartilage tympanoplasty for posterosuperior retraction pockets of the pars tensa in children. Otol Neurotol 2003; 24: 264-269
146 Ramakrishnan Y, Kotecha A, Bowdler DA. A review of retraction pockets: past, present and future management. J Laryngol Otol 2007; 121: 521-525
147 Müller J. Ueber den feineren Bau und die Formen der krankhaften Geschwulste. Berlin: G. Reimer; 1838
148 Thomas JP, Volkenstein S, Minovi A, Dazert S. Aktuelle Aspekte des kindlichen Cholesteatoms. HNO 2013; 61: 380-387
149 Derlacki EL, Clemis JD. Congenital cholesteatoma of the middle ear and mastoid. Ann Otol Rhinol Laryngol 1965; 74: 706-727
150 Levenson MJ, Parisier SC, Chute P, Wenig S, Juarbe C. A review of twenty congenital cholesteatomas of the middle ear in children. Otolaryngol Head Neck Surg 1986; 94: 560-567
151 Sudhoff H, Liang J, Dazert S, Borkowski G, Michaels L. Zur Rolle der „Epidermoid Formations“ in der Pathogenese des kongenitalen Cholesteatoms – eine aktuelle Übersicht. Laryngorhinootologie 1999; 78: 63-67
152 Sudhoff H, Tos M. Pathogenesis of attic cholesteatoma: clinical and immunohistochemical support for combination of retraction theory and proliferation theory. Am J Otol 2000; 21: 786-792
153 Nevoux J, Lenoir M, Roger G et al. Childhood cholesteatoma. Eur Ann Otorhinolaryngol Head Neck Dis 2010; 127: 143-150
154 Dominguez S, Harker LA. Incidence of cholesteatoma with cleft palate. Ann Otol Rhinol Laryngol 1988; 97: 659-660
155 Nelson M, Roger G, Koltai PJ et al. Congenital cholesteatoma: classification, management, and outcome. Arch Otolaryngol Head Neck Surg 2002; 128: 810-814
156 Iino Y, Nagamine H, Sasaki Y, Kodera K. Hearing results of canal wall reconstruction tympanoplasty for middle ear cholesteatoma in children. International Journal of Pediatric Otorhinolaryngology 2001; 60: 65-72
157 Lee DH, Kim CS, Park CW, Chung DY. Is preoperative computed tomographic density measurement of soft tissues helpful in the diagnosis of cholesteatoma?. Ann Otol Rhinol Laryngol 2012; 121: 792-797
158 Plester D, Hildmann H, Steinbach E. Atlas der Ohrchirurgie. Stuttgart: Kohlhammer; 1989
159 Minovi A, Venjacob J, Volkenstein S, Dornhoffer J, Dazert S. Functional results after cholesteatoma surgery in an adult population using the retrograde mastoidectomy technique. Eur Arch Otorhinolaryngol 2013;
160 Roth TN, Haeusler R. Inside-out technique cholesteatoma surgery: a retrospective long-term analysis of 604 operated ears between 1992 and 2006. Otol Neurotol 2009; 30: 59-63
161 Jahnke K, Khatib M, Rau U. Langzeitergebnisse nach Cholesteatomchirurgie. Laryngol Rhinol Otol (Stuttg) 1985; 64: 238-242
162 Presutti L, Marchioni D, Mattioli F, Villari D, Alicandri-Ciufelli M. Endoscopic management of acquired cholesteatoma: our experience. J Otolaryngol Head Neck Surg 2008; 37: 481-487
163 Potsic WP, Samadi DS, Marsh RR, Wetmore RF. A staging system for congenital cholesteatoma. Arch Otolaryngol Head Neck Surg 2002; 128: 1009-1012
164 Dodson EE, Hashisaki GT, Hobgood TC, Lambert PR. Intact canal wall mastoidectomy with tympanoplasty for cholesteatoma in children. Laryngoscope 1998; 108: 977-983
165 Tos M, Lau T. Late results of surgery in different cholesteatoma types. ORL J Otorhinolaryngol Relat Spec 1989; 51: 33-49
166 Stangerup SE, Drozdziewicz D, Tos M. Cholesteatoma in children, predictors and calculation of recurrence rates. International journal of pediatric otorhinolaryngology 1999; 49 (Suppl. 01) S69-S73
167 Visvanathan V, Kubba H, Morrissey MS. Cholesteatoma surgery in children: 10-year retrospective review. J Laryngol Otol 2012; 126: 450-453
168 Stapleton AL, Egloff AM, Yellon RF. Congenital cholesteatoma: predictors for residual disease and hearing outcomes. Arch Otolaryngol Head Neck Surg 2012; 138: 280-285
169 Migirov L, Tal S, Eyal A, Kronenberg J. MRI, not CT, to rule out recurrent cholesteatoma and avoid unnecessary second-look mastoidectomy. Isr Med Assoc J 2009; 11: 144-146
170 Profant M, Slavikova K, Kabatova Z, Slezak P, Waczulikova I. Predictive validity of MRI in detecting and following cholesteatoma. Eur Arch Otorhinolaryngol 2012; 269: 757-765
171 Dubrulle F, Souillard R, Chechin D et al. Diffusion-weighted MR imaging sequence in the detection of postoperative recurrent cholesteatoma. Radiology 2006; 238: 604-610
172 Vercruysse JP, De Foer B, Pouillon M et al. The value of diffusion-weighted MR imaging in the diagnosis of primary acquired and residual cholesteatoma: a surgical verified study of 100 patients. Eur Radiol 2006; 16: 1461-1467
173 Koitschev A, Behringer P, Bogner D et al. Does diffusion-weighted MRI (DW-MRI) change treatment strategy in pediatric cholesteatoma?. Acta Otolaryngol 2013; 133: 443-448
174 Geoffray A, Guesmi M, Nebbia JF et al. MRI for the diagnosis of recurrent middle ear cholesteatoma in children – can we optimize the technique? Preliminary study. Pediatr Radiol 2012;
175 Shirazi MA, Muzaffar K, Leonetti JP, Marzo S. Surgical treatment of pediatric cholesteatomas. Laryngoscope 2006; 116: 1603-1607
176 Yung M, Jacobsen NL, Vowler SL. A 5-year observational study of the outcome in pediatric cholesteatoma surgery. Otol Neurotol 2007; 28: 1038-1040
177 Stankovic MD. Audiologic results of surgery for cholesteatoma: short- and long-term follow-up of influential factors. Otol Neurotol 2008; 29: 933-940
178 Osborn AJ, Papsin BC, James AL. Clinical indications for canal wall-down mastoidectomy in a pediatric population. Otolaryngol Head Neck Surg 2012; 147: 316-322
179 McRackan TR, Abdellatif WM, Wanna GB et al. Evaluation of second look procedures for pediatric cholesteatomas. Otolaryngol Head Neck Surg 2011; 145: 154-160
180 Tietze L, Papsin B. Utilization of bone-anchored hearing aids in children. International journal of pediatric otorhinolaryngology 2001; 58: 75-80
181 McDermott AL, Sheehan P. Bone anchored hearing aids in children. Curr Opin Otolaryngol Head Neck Surg 2009; 17: 488-493
182 McDermott AL, Sheehan P. Paediatric Baha. Adv Otorhinolaryngol 2011; 71: 56-62
183 Roman S, Nicollas R, Triglia JM. Practice guidelines for bone-anchored hearing aids in children. Eur Ann Otorhinolaryngol Head Neck Dis 2011; 128: 253-258
184 Battista RA, Ho S. The Bone-Anchored Hearing Device. Operat Tech Oto-laryngol Head Neck Surg 2003; 14: 272-276
185 Priwin C, Stenfelt S, Granstrom G, Tjellstrom A, Hakansson B. Bilateral bone-anchored hearing aids (BAHAs): an audiometric evaluation. Laryngoscope 2004; 114: 77-84
186 Davids T, Gordon KA, Clutton D, Papsin BC. Bone-anchored hearing aids in infants and children younger than 5 years. Arch Otolaryngol Head Neck Surg 2007; 133: 51-55
187 Arndt S, Kromeier J, Berlis A et al. Imaging procedures after bone-anchored hearing aid implantation. Laryngoscope 2007; 117: 1815-1818
188 Fritsch MH, Naumann IC, Mosier KM. BAHA devices and magnetic resonance imaging scanners. Otol Neurotol 2008; 29: 1095-1099
189 Saliba I, Froehlich P, Bouhabel S. One-stage vs. two-stage BAHA implantation in a pediatric population. International journal of pediatric otorhinolaryngology 2012; 76: 1814-1818
190 de Wolf MJ, Hol MK, Mylanus EA, Snik AF, Cremers CW. Benefit and quality of life after bone-anchored hearing aid fitting in children with unilateral or bilateral hearing impairment. Arch Otolaryngol Head Neck Surg 2011; 137: 130-138
191 Holgers KM. Characteristics of the inflammatory process around skin-penetrating titanium implants for aural rehabilitation. Audiology 2000; 39: 253-259
192 Monksfield P, Ho EC, Reid A, Proops D. Experience with the longer (8.5 mm) abutment for Bone-Anchored Hearing Aid. Otol Neurotol 2009; 30: 274-276
193 McDermott AL, Williams J, Kuo M, Reid A, Proops D. The birmingham pediatric bone-anchored hearing aid program: a 15-year experience. Otol Neurotol 2009; 30: 178-183
194 D’Eredita R, Caroncini M, Saetti R. The new Baha implant: a prospective osseointegration study. Otolaryngol Head Neck Surg 2012; 146: 979-983
195 Mlynski R, Rak K, Harnisch W et al. Funktionelle Ergebnisse bei der Versorgung mit dem aktiven Knochleitungsimplantat BoneBridge^®. In: 84 Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie. Nürnberg: German Medical Science GMS Publishing House; 2013
196 Dazert S, Shehata-Dieler WE, Dieler R, Helms J. Das Mittelohrimplantat „Vibrant Soundbridge“ zur Hörrehabilitation bei sensorischer Schwerhörigkeit. I. Klinik, Indikation und erste Ergebnisse. Laryngorhinootologie 2000; 79: 459-464
197 Lenarz T, Weber BP, Mack KF, Battmer RD, Gnadeberg D. Vibrant Soundbridge System: Ein neuartiges Hörimplantat für Innenohrschwerhörige. Teil 1: Funktionsweise und erste klinische Erfahrungen. Laryngorhinootologie 1998; 77: 247-255
198 Sprinzl GM, Wolf-Magele A, Schnabl J, Koci V. Das aktive Mittelohrimplantat in der Rehabilitation von sensorineuralen, kombinierten und Schallleitungs-Hörstörungen. Laryngorhinootologie 2011; 90: 560-572
199 Zenner HP. Implantierbare Hörgeräte – der aktuelle Stand. Laryngorhinootologie 2000; 79 (Supplement 2) 141-161
200 Cremers CW, O’Connor AF, Helms J et al. International consensus on Vibrant Soundbridge(R) implantation in children and adolescents. International journal of pediatric otorhinolaryngology 2010; 74: 1267-1269
201 Colletti V, Soli SD, Carner M, Colletti L. Treatment of mixed hearing losses via implantation of a vibratory transducer on the round window. Int J Audiol 2006; 45: 600-608
202 Frenzel H, Hanke F, Beltrame M et al. Application of the Vibrant Soundbridge to unilateral osseous atresia cases. Laryngoscope 2009; 119: 67-74
203 Colletti L, Mandala M, Colletti V. Long-term Outcome of Round Window Vibrant SoundBridge Implantation in Extensive Ossicular Chain Defects. Otolaryngol Head Neck Surg 2013; 149: 134-141