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Horm Metab Res 2014; 46(05): 354-359
DOI: 10.1055/s-0033-1363224
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Differential Impact of Changes in Adiposity Distribution on Insulin Resistance and Adiponectin Variations Over 4 Years in Normal Weight Young Adults

G. Lacerte
1   Centre de recherche clinique Etienne-LeBel, Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada
,
M.-F. Langlois
1   Centre de recherche clinique Etienne-LeBel, Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada
2   Department of Medicine, Division of Endocrinology, Université de Sherbrooke, Sherbrooke, QC, Canada
,
M. Doyon
1   Centre de recherche clinique Etienne-LeBel, Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada
,
C. Brown
1   Centre de recherche clinique Etienne-LeBel, Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada
,
A. C. Carpentier
1   Centre de recherche clinique Etienne-LeBel, Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada
2   Department of Medicine, Division of Endocrinology, Université de Sherbrooke, Sherbrooke, QC, Canada
,
M.-F. Hivert
1   Centre de recherche clinique Etienne-LeBel, Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada
2   Department of Medicine, Division of Endocrinology, Université de Sherbrooke, Sherbrooke, QC, Canada
3   General Medicine Division, Massachusetts General Hospital, Boston, MA, USA
› Author Affiliations
Further Information

Publication History

received 07 July 2013

accepted 19 November 2013

Publication Date:
20 January 2014 (online)

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Abstract

The aim of the study was to evaluate the influence of weight gain and changes in adiposity distribution on insulin resistance and circulating adiponectin variations over 4 years in free-living normal weight young adults. In this prospective observational cohort (n=42 women, 18 men), anthropometric measurements and blood samples were collected in the fasting state at baseline and at 4 years. Insulin resistance was estimated using the homeostatic model assessment (HOMA-IR). Circulating adiponectin levels were determined by radioimmunoassay. To investigate increase in adiposity more specifically, subsidiary analyses were performed in a subgroup of individuals (n=31) who gained adiposity over the course of the 4-year follow-up (defined as gain >1% in percent body fat). Regression analyses were performed to adjust for sex, age, parental education, lifestyle, and fitness levels. At baseline, the participants were young adults (age=20.0 years old) in the normal weight range [body mass index (BMI)=22.7 kg/m2 (IQR=21.1–24.4)]. Median change in body fat percentage was +1.4% (IQR=−0.3–3.4; p=0.01) and in waist circumference was +1.2 cm (IQR=−2.6–5.3; p=0.05). In the subgroup of individuals who gained more than 1% body fat, increase in HOMA-IR was associated with an increase in BMI (r=0.44; p=0.01; p<0.01 in fully adjusted model), while decrease in adiponectin levels was associated with an increase in waist circumference (r=−0.38; p=0.03) but this was no longer significant after adjustment for sex and other potential confounders (p=0.14). In a population of young adults, small variations in adiposity within the normal weight range were associated with increase in insulin resistance.

Key words

weight gain - waist circumference - percent body fat - adiponectin - insulin resistance - young adults

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    for this article is available online at http://www.thieme-connect.de/ejournals/toc/hmr
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