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Exp Clin Endocrinol Diabetes 2014; 122(03): 149-153
DOI: 10.1055/s-0033-1363260
Article
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Mini-fasting Tests Diagnosing Endogenous Hyperinsulinism: a Follow-up of 26 Cases

J. S. Felício
1   Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil
2   Endocrinology Division, Hospital Brigadeiro, Avenida Brigadeiro Luis Antonio, Jardim Paulista, São Paulo, São Paulo, Brazil
,
C. C. Koury
1   Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil
,
C. L. L. P. Martins
1   Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil
,
K. B. Miléo
1   Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil
,
J. F. A. Neto
1   Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil
,
F. T. C. de Melo
1   Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil
,
A. C. C. B. de Souza
1   Endocrinology Division, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Rua dos Mundurucus, Guamá, Belém, Pará, Brazil
› Institutsangaben
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Publikationsverlauf

received 23. Juni 2013
first decision 29. November 2013

accepted 02. Dezember 2013

Publikationsdatum:
18. März 2014 (online)

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Abstract

Context:

The supervised 72-h fast remains the gold standard test for the diagnosis of endogenous hyperinsulinism and has recently been suggested to be shortened or even avoided.

Objective:

This study aimed to evaluate whether measurement of blood glucose, insulin and C-peptide levels after a 12 h overnight fast (mini-fasting test), in at least 3 consecutive days, could allow making or ruling out diagnosis of endogenous hyperinsulinism, according to the Endocrine Society’s recent guidelines.

Patients and methods:

We performed 12 h mini-fasting test in at least 3 consecutive days, dosing blood glucose, insulin and C-peptide levels in 26 inpatient patients with pathologically proven endogenous hyperinsulinism.

Results:

In our series, 100% of patients showed insulin levels of at least 3 μU/ml and C-peptide levels of at least 0.6 ng/ml concomitant with symptomatic hypoglycemia (≤55 mg/dl).

Conclusion:

It leads to the conclusion that mini-fasting test might avoid, in most cases, prolonged fasting test for the diagnosis of hypoglycemia due to endogenous hyperinsulinism.

Key words

endocrine pancreas - hypoglycemia - insulinoma
 

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