J Neurol Surg Rep 2014; 75(01): e62-e66
DOI: 10.1055/s-0033-1363505
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Primary Neurolymphomatosis of the Lower Cranial Nerves Presenting as Dysphagia and Hoarseness: A Case Report

Naoto Sakai
1   Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, Higashiku, Hamamatsu, Japan
,
Tae Ito-Yamashita
1   Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, Higashiku, Hamamatsu, Japan
,
Goro Takahashi
2   Department of Otolaryngology, Hamamatsu University School of Medicine, Handayama, Higashiku, Hamamatsu, Japan
,
Satoshi Baba
3   Department of Diagnostic Pathology, Hamamatsu University School of Medicine, Handayama, Higashiku, Hamamatsu, Japan
,
Shinichiro Koizumi
1   Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, Higashiku, Hamamatsu, Japan
,
Tomohiro Yamasaki
1   Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, Higashiku, Hamamatsu, Japan
,
Tsutomu Tokuyama
1   Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, Higashiku, Hamamatsu, Japan
,
Hiroki Namba
1   Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, Higashiku, Hamamatsu, Japan
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Publikationsverlauf

29. Dezember 2012

03. November 2013

Publikationsdatum:
16. Januar 2014 (online)

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Abstract

Primary neurolymphomatosis is an extremely rare tumor. We report the case of a 74-year-old patient presenting with dysphagia and hoarseness. Initial contrast-enhanced computed tomography of the head, neck, and chest did not reveal any lesions. His symptoms improved with short-term administration of prednisone but recurred and deteriorated. Magnetic resonance (MR) imaging revealed a tumor along the ninth and tenth cranial nerves across the jugular foramen. Fluorine-18 fluorodeoxyglucose positron emission tomography indicated this was a primary tumor. Repeated MR imaging after 2 months revealed considerable tumor enlargement. A left suboccipital craniotomy was performed to remove the tumor that infiltrated the ninth and tenth cranial nerves. The histopathologic diagnosis was diffuse large B-cell lymphoma. Although focal radiation therapy was administered to ensure complete eradication of the tumor, the patient died of aspiration pneumonia with systemic metastasis. To our knowledge, this is the first reported case of primary neurolymphomatosis in the lower cranial nerves.