Schwere disseminierte Infektion durch Mycobacterium bovis BCG als Folge einer intravesikalen BCG-Therapie: Diagnostische Herausforderungen und therapeutische Optionen

Zusammenfassung

Wir präsentieren den Fall eines 65-jährigen Patienten, der an einem oberflächlichen Harnblasenkarzinom leidet und infolge einer intravesikalen BCG-Therapie eine kritische systemische inflammatorische Reaktion aufgrund einer Disseminierung von Mycobacterium bovis BCG in Leber und Lunge erlitt. Neben der antituberkulotischen Therapie unter Beachtung einer Primärresistenz des M. bovis BCG gegenüber PZA diskutieren wir, basierend auf publizierten Fallberichten, die Möglichkeiten einer immunmodulierenden Therapie mit Steroiden [1].

Abstract

We present the case of a 65-year-old patient with superficial carcinoma of the bladder who developed systemic inflammatory reaction as a result of a severe disseminated infection with M. bovis BCG after intravesical instillation of BCG. Besides the recommended antituberculosis therapy, considering the resistance of M. bovis to PZA, we discuss here the option of using steroids in the therapeutic management of this patient.

• Literatur

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