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Planta Med 2014; 80(05): 419-425
DOI: 10.1055/s-0034-1368252
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

New Clerodane Diterpenes from Tinospora sagittata var. yunnanensis

Zhi-Yong Jiang
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Yunnan, P. R. China
,
Wen-Juan Li
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Yunnan, P. R. China
,
Li-Xiang Jiao
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Yunnan, P. R. China
,
Jun-Ming Guo
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Yunnan, P. R. China
,
Kai Tian
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Yunnan, P. R. China
,
Chun-Tao Yang
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Yunnan, P. R. China
,
Xiang-Zhong Huang
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Yunnan, P. R. China
2   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China
› Author Affiliations
Further Information

Publication History

received 25 September 2013
revised 22 January 2014

accepted 14 February 2014

Publication Date:
14 March 2014 (online)

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Abstract

Four new clerodane diterpenes, namely sagittatayunnanosides A–D (1–4), were isolated from the roots of Tinospora sagittata var. yunnanensis, together with two known compounds, tinospinoside C (5) and tinospinoside E (6). The structures of the four new compounds were well elucidated by extensive analyses of the MS, IR, and 1D and 2D NMR data. The cytotoxic and antifouling activities of compounds 1–6 were evaluated.

Key words

Tinospora sagittata var. Yunnanensis - Menispermaceae - clerodane diterpenes - cytotoxicity - antifouling activity

Supporting Information

 

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