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Planta Med 2014; 80(06): 458-464
DOI: 10.1055/s-0034-1368300
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Chemical and Pharmacological Investigation of the Stem Bark of Synadenium grantii

Antonio C. M. Munhoz
1   Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil
,
Bruno R. Minozzo
1   Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil
,
Luiza S. Cruz
1   Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil
,
Thaís L. Oliveira
1   Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil
,
Willian M. Machado
1   Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil
,
Airton V. Pereira
1   Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil
,
Daniel Fernandes
1   Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil
,
Francine A. Manente
2   Department of Clinical and Toxicological Analysis, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil
,
José C. R. Vellosa
2   Department of Clinical and Toxicological Analysis, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil
,
Angelita Nepel
3   NMR Center, Federal University of Paraná, Curitiba, Paraná, Brazil
,
Andersson Barison
3   NMR Center, Federal University of Paraná, Curitiba, Paraná, Brazil
,
Flávio L. Beltrame
1   Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil
› Author Affiliations
Further Information

Publication History

received 11 September 2013
revised 28 February 2014

accepted 01 March 2014

Publication Date:
31 March 2014 (online)

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Abstract

Based on the fact that Synadenium grantii is used in folk medicine for the treatment of peptic ulcers and inflammatory diseases, this work describes its chemical and pharmacological properties. Pharmacological investigation of the crude bark extract showed a high antioxidant activity over several scavenger systems, such as 2,2′-azino-bis (3-ethylenebenzothiazoline-6-sulfonic acid)• +, 1-diphenyl-2-picrylhydrazyl•, O2 • − , and HOCl, as well as an enzymatic system with human myeloperoxidase and an ex vivo hemolysis system. Furthermore, the oral administration of the crude bark extract was able to reduce carrageenan-induced rat paw edema as effectively as ibuprofen. These biological activities may be associated with the presence of flavonoids and terpenes, as revealed by HPLC and NMR analyses of the crude stem bark extract. The phytochemical investigations in this study resulted in the isolation of friedelin and 3β-friedelinol for the first time, while euphol and lanosterol were also isolated.

Key words

Synadenium grantii - Euphorbiaceae - antioxidant activity - anti-inflammatory activity - flavonoids - terpenes

Supporting Information

 

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