Tremor: Pathophysiologische Konzepte und Ergebnisse der Tiefen Hirnstimulation

Kernaussagen

• Tremor ist ein Netzwerkphänomen, zu dem insbesondere die zerebello-thalamo-kortikale und die Basalganglienschleife beitragen.

• Tremor-Patienten zeigen eine pathologische Hypersynchronisation zwischen den Arealen des Tremornetzwerks.

• Tremor kann durch Tiefe Hirnstimulation im VIM, STN oder GPi effizient reduziert werden.

• Bei der Wahl des Zielpunkts sind neben dem Schweregrad des Tremors auch die weiteren Symptome und mögliche Nebenwirkungen in Betracht zu ziehen.

• Literatur

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