Systemische Mastzellaktivierungserkrankung: Ein praxisorientierter Leitfaden zu Diagnostik und Therapie

Zusammenfassung

In der vorliegenden Arbeit werden die klinischen Erscheinungsbilder der systemischen Mastzellaktivierungserkrankung, die pathogenetischen Zusammenhänge und diagnostischen Algorithmen sowie Therapieoptionen dargestellt. Dies soll den Leser in die Lage versetzen, eine systemische Mastzellaktivierungserkrankung zu erkennen, differenzialdiagnostisch einzugrenzen sowie eine Therapie empfehlen zu können. Bei chronischen unklaren multisystemischen Beschwerden sollte die systemische Mastzellaktivierungserkrankung frühzeitig in die differenzialdiagnostischen Überlegungen einbezogen werden. Mit spezifischen, wenig invasiven Untersuchungsverfahren kann in den meisten Fällen die Diagnose gesichert und eine erkrankungsgerechte, an der individuellen Symptomatik orientierte Therapie eingeleitet werden.

Abstract

In the present paper clinical phenotypes, pathogenetic relationships, and diagnostic algorithms as well as therapeutic concepts of/for systemic mast cell activation disease are reviewed. The reader should be able to recognize and diagnose a systemic mast cell activation disease, as well as to counsel a personalized drug therapy. In the case of chronic multisystem polymorbidity systemic mast cell activation disease should be considered as a differential diagnosis at an early stage. In most cases, specific, little invasive investigations allow diagnosing the disease and, hence, an appropriate therapy can be initiated.

Schlüsselwörter

Mastzellaktivierungserkrankung - systemische Mastozytose - Mastzellaktivierungssyndrom - Reizdarm - Fibromyalgie

Keywords

mast cell activation disease - systemic mastocytosis - mast cell activation syndrome - irtritable bowel - fibromyalgia

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