Semin Hear 2014; 35(02): 131-144
DOI: 10.1055/s-0034-1372529
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Tinnitus: Mechanisms Induced from Human Functional Neuroimaging Studies

Audrey Maudoux
1   Cyclotron Research Centre, University of Liège (ULg)
2   Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Erasme Hospital, University of Brussels (ULB), Brussels, Belgium
,
Philippe Lefebvre
3   Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital of Liège, University of Liège (ULg), Liège, Belgium
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Publikationsdatum:
29. April 2014 (online)

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Abstract

The past 15 years has provided an unprecedented collection of discoveries that bear upon our scientific understanding of the pathophysiology of tinnitus. Highlighted among these discoveries is the fact that changes of brain activity accompany tinnitus. All tinnitus theories refer to common concepts. First, peripheral lesions in the cochlea or the auditory nerve produce dysfunctional input to central auditory structures and induce changes in the auditory system. Associated to plastic changes in central auditory structures, neuroimaging studies show signs of the implication of extra-auditory regions in tinnitus pathophysiology. Collectively, these observations have led to important new insights into the understanding of tinnitus. Here, we review the advances made in this field of research using human functional neuroimaging methods.