Lipid Peroxidation and Altered Anti-oxidant Status in Breast Adenocarcinoma Patients

Abstract

Introduction: Breast cancer is the one of most common cancer in worldwide which accounts for high mortality rate. Accumulating evidences emphasizes increased oxidative stress plays a major role in the pathogenesis of solid tumors. Hence the current study was carried out to measure the extent of lipid peroxidation and antioxidants as biomarkers of human breast ade­no­carcinoma patients.

Methods: The collected tissues and blood samples from cancer patients and control groups were subjected to determine the extent of lipid peroxidation by measuring the levels of malondialdehyde (MDA), lipid hydroperoxides (LOOH) and conjugated dienes (CDs) as well as the status of the antioxidants such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) by UV visible spectrophotometer.

Results: Lipid peroxidation in breast cancer tissues was significantly enhanced in conjunction with the significant increase in both enzymic and non-enzymic antioxidants when compared to the healthy controls.

Conclusion: Increased lipid peroxidation is more pronounced in breast cancer patients and as a adaptive mechanism antioxidants system was upregulated. Therefore, measurement of oxidative stress will be an affective prognosis factor and that may aid to design new therapeutic drugs for cancer treatment.

Key words

oxidative stress - antioxidants - breast cancer - lipid peroxidation - ROS

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