Emerging Roles of MicroRNA in the Embryo–Endometrium Cross Talk

Uri P. Dior; Liron Kogan; Henry H. Chill; Neta Eizenberg; Alexander Simon; Ariel Revel

doi:10.1055/s-0034-1376359

Seminars in Reproductive Medicine, Inhaltsverzeichnis

Semin Reprod Med 2014; 32(05): 402-409
DOI: 10.1055/s-0034-1376359

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Emerging Roles of MicroRNA in the Embryo–Endometrium Cross Talk

Autor*innen

Uri P. Dior

¹Department of Obstetrics and Gynecology, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel
Liron Kogan

¹Department of Obstetrics and Gynecology, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel
Henry H. Chill

¹Department of Obstetrics and Gynecology, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel
Neta Eizenberg

²Department of Obstetrics and Gynecology, Rabin Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel
Alexander Simon

¹Department of Obstetrics and Gynecology, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel
Ariel Revel

¹Department of Obstetrics and Gynecology, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel

Abstract

Embryo implantation requires a reciprocal interaction between the blastocyst and endometrium and is associated with complex regulatory mechanisms. Since their discovery, microRNAs have become prominent regulatory candidates, providing missing links for many biological pathways. In recent years, microRNAs have been implicated as one of the important players in the regulation of multiple physiological functions of the endometrium. This review aims to present recent knowledge pertaining to the diverse aspects of microRNAs in the embryo–endometrial cross talk. We will focus on the role of microRNAs in decidualization. Next, we will review recent studies investigating the role of microRNAs in recurrent pregnancy loss. Finally, we will discuss the role of microRNAs in the tissue invasion of implantation and compare that with tissue invasion in cancers.

Keywords

microRNA - endometrium - implantation - decidualization - recurrent pregnancy loss

Volltext

Referenzen

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