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Synthesis 2014; 46(18): 2499-2505
DOI: 10.1055/s-0034-1378316
DOI: 10.1055/s-0034-1378316
paper
Transition-Metal-Free Heterocyclization of 1,3-Diynes with Nitriles in the Presence of Aqueous Potassium Hydroxide: Synthesis of 2,4-Disubstituted 5-[(E)-2-Phenylethenyl]-1,3-oxazoles
Weitere Informationen
Publikationsverlauf
Received: 17. März 2014
Accepted after revision: 20. Mai 2014
Publikationsdatum:
24. Juni 2014 (online)

Abstract
A transition-metal-free heterocyclization of 1,3-diynes and nitriles in the presence of either aqueous potassium hydroxide or cesium hydroxide in 1,4-dioxane at 100 °C was realized. This method provided stereoselectively 2,4-disubstituted 5-[(E)-2-phenylethenyl]-1,3-oxazoles in moderate to good yields.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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