Efficient Synthesis of Jolkinolides A and B from Steviol

Abstract

Jolkinolides, isolated from Euphorbia fischeriana Steud, are naturally occurring tetracyclic ent-abietane diterpenes, some of which exhibit promising antitumor and other biological activity. An efficient strategy for the synthesis of jolkinolides A and B is described starting from readily available steviol in 10 and 11 steps with total yields of over 10%, respectively.

Key words

ent-abietane diterpenes - jolkinolides - steviol - Wittig–Horner reaction - antitumor activity

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