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Synthesis 2014; 46(23): 3263-3267
DOI: 10.1055/s-0034-1378554
DOI: 10.1055/s-0034-1378554
paper
Synthesis of 4-Halogenated 3-Fluoro-6-methoxyquinolines: Key Building Blocks for the Synthesis of Antibiotics
Weitere Informationen
Publikationsverlauf
Received: 11. Juni 2014
Accepted after revision: 07. Juli 2014
Publikationsdatum:
28. August 2014 (online)
Abstract
A practical and scalable 4-step route is presented for the synthesis of 4-bromo-3-fluoro-6-methoxyoquinoline and 3-fluoro-4-iodo-6-methoxyoquinoline from readily available 2,4-dichloro-3-fluoroquinoline with an overall yield of 81–85%. Halogenated quinoline building blocks have found much use in antimicrobial drug discovery, and the method reported here would be useful for the synthesis of these compounds.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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