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Synthesis 2014; 46(23): 3221-3228
DOI: 10.1055/s-0034-1378616
DOI: 10.1055/s-0034-1378616
paper
A New Synthetic Route Towards Aliskiren Intermediates
Further Information
Publication History
Received: 14 May 2014
Accepted after revision: 18 July 2014
Publication Date:
21 August 2014 (online)
Abstract
The synthesis of aliskiren intermediates was accomplished by attaching the 3,4-dialkoxyphenyl unit to precursor C-8 lactone-carboxylic acid derivatives using organometallic reagents. Totally different reactivities of the lactone-carboxylic acid chloride substrate towards organomagnesium and organoboron reagents were observed.
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