Synthesis 2014; 46(23): 3207-3212
DOI: 10.1055/s-0034-1378617
paper
© Georg Thieme Verlag Stuttgart · New York

Domino Reaction of 2,2-Dihydroxyindene-1,3-dione with Aromatic Amines: Efficient Synthesis of Isochromeno[4,3-b]indol-5(11H)-one Derivatives

Xiao-Yan Meng
,
Mu-Yan Sun
,
Fu-Jie Zhao
,
Yi-Jing Dang
,
Bo Jiang*
,
Shu-Jiang Tu*
Further Information

Publication History

Received: 15 April 2014

Accepted after revision: 17 July 2014

Publication Date:
21 August 2014 (online)


Abstract

An efficient approach to 16 examples of polyfunctionalized isochromeno[4,3-b]indol-5(1H)-one derivatives, obtained in 60–85% yield and with excellent regioselectivity, has been developed through a domino reaction of 2,2-dihydroxyindene-1,3-dione with aromatic amines under microwave irradiation. The atom- and step-economy and scope make this reaction a powerful tool for assembling polyheterocyclic scaffolds of general chemical and biomedical interest.

Supporting Information

 
  • References

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