Copper(II) Triflate Catalyzed Synthesis of 2,4-Disubstituted Oxazoles from α-Diazoketones

M. Ramana Reddy; G. Niranjan Reddy; Umer Mehmood; Ibnelwaleed A. Hussein; S. U. Rahman; Khalil Harrabi; Basireddy V. Subba Reddy

doi:10.1055/s-0034-1378860

Synthesis, Table of Contents

Synthesis 2015; 47(21): 3315-3320
DOI: 10.1055/s-0034-1378860

paper

Copper(II) Triflate Catalyzed Synthesis of 2,4-Disubstituted Oxazoles from α-Diazoketones

M. Ramana Reddy

^aNatural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India Email: basireddy@iict.res.in

,

G. Niranjan Reddy

^aNatural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India Email: basireddy@iict.res.in

,

Umer Mehmood

^bDepartment of Chemical Engineering, King Fahd University of Petroleum & Minerals (KFUPM), Dhahran 31261, Kingdom of Saudi Arabia

,

Ibnelwaleed A. Hussein

^bDepartment of Chemical Engineering, King Fahd University of Petroleum & Minerals (KFUPM), Dhahran 31261, Kingdom of Saudi Arabia

,

S. U. Rahman

^bDepartment of Chemical Engineering, King Fahd University of Petroleum & Minerals (KFUPM), Dhahran 31261, Kingdom of Saudi Arabia

,

Khalil Harrabi

^cDepartment of Physics, King Fahd University of Petroleum & Minerals (KFUPM), Dhahran 31261, Kingdom of Saudi Arabia

,

Basireddy V. Subba Reddy*

^aNatural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India Email: basireddy@iict.res.in

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Abstract

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Abstract

A novel method is devised for the synthesis of 2,4-disubstituted oxazole derivatives via the coupling of α-diazoketones with amides using copper(II) triflate as the catalyst. The synthetic versatility of this approach is exemplified in the synthesis of an analogue of balsoxin.

Key words

α-diazoketones - amides - copper(II) triflate - oxazoles

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References

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