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Synthesis 2015; 47(22): 3611-3617
DOI: 10.1055/s-0034-1378875
DOI: 10.1055/s-0034-1378875
paper
Enaminone-Based Three-Component Reactions for the Diastereoselective Synthesis of Fused Tetrahydropyridines
Further Information
Publication History
Received: 08 May 2015
Accepted after revision: 03 July 2015
Publication Date:
14 August 2015 (online)
![](https://www.thieme-connect.de/media/synthesis/201522/lookinside/thumbnails/ss-2015-h0304-op_10-1055_s-0034-1378875-1.jpg)
Abstract
An environmentally benign multicomponent synthetic method has been realized for the diastereoselective construction of fused tetrahydropyridines. Structurally diverse products have been acquired with generally good yields via the assembly of simple starting materials, enaminones or nitroenamines, o-aminophenols, and cinnamaldehydes, in the presence of lactic acid in water–ethanol media.
Key words
enaminone - transamination - multicomponent reaction - polycyclic product - aqueous synthesisSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1378875.
- Supporting Information
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For reviews, see:
For selected recent reviews on MCRs, see:
For reviews on enaminone-based synthesis:
For selected recent references:
For a review, see:
For selected examples, see:
For references on biological function of tetrahydropyridines, see:
For the application of lactic acid in organic synthesis, see: