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Synthesis 2015; 47(02): 181-186
DOI: 10.1055/s-0034-1379206
DOI: 10.1055/s-0034-1379206
paper
Microwave-Assisted Copper-Catalyzed Cross-Coupling Reaction of Thiols with Aryl Iodides in Water
Weitere Informationen
Publikationsverlauf
Received: 26. Juli 2014
Accepted after revision: 01. September 2014
Publikationsdatum:
15. Oktober 2014 (online)
![](https://www.thieme-connect.de/media/synthesis/201502/lookinside/thumbnails/10.1055-s-0034-1379206-1.jpg)
Abstract
Microwave-promoted C–S bond formation from thiols and aryl iodides in the presence of a copper catalyst is reported. A combination of copper(II) oxide and 1,10-phenanthroline catalyzes this reaction. A variety of aryl iodides react smoothly with thiols to provide the corresponding aryl sulfides in good to excellent yields. Notably, the reactions proceed in water with a short reaction time (30 minutes). This system shows broad functional-group tolerance; amino, chloro, bromo, acetyl, and nitro groups are unaffected by the reaction conditions.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084. Included are 1H and 13C NMR spectra for compounds 3a–v.
- Supporting Information
-
References
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