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Synlett 2014; 25(19): 2781-2786
DOI: 10.1055/s-0034-1379249
DOI: 10.1055/s-0034-1379249
letter
Palladium-Catalyzed Direct Amination of Allylic Alcohols at Room Temperature
Further Information
Publication History
Received: 28 July 2014
Accepted after revision: 15 September 2014
Publication Date:
16 October 2014 (online)
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Abstract
A palladium complex ligated with Xantphos has been identified as an efficient catalyst for the catalytic amination of allylic alcohols, which allows the direct amination of allylic alcohols with amines to proceed at room temperature in the absence of additives. The method is compatible with a variety of functional groups and can be used to prepare a wide range of linear allylic amines in good to excellent yields with high stereoselectivities.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
- Supporting Information
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For selected reviews on the synthesis of allylic amines, see:
For palladium-catalyzed amination of allylic halides and allylic pseudohalides, see:
For palladium-catalyzed amination of allylic alcohol with additive, see:
For palladium-catalyzed amination of allylic alcohol without additive at high temperature, see:
For platinum-catalyzed amination of allylic alcohol without additive at high temperature, see: