Three-Component Domino Heteroannulation and Synthesis of Some Novel Hexahydropyrimido[4,5-b]-1,8-naphthyridine Derivatives

Abstract

An efficient protocol has been developed for the synthesis of some novel hexahydropyrimido[4,5-b]-1,8-naphthyridine derivatives by a one-pot three-component reaction of a 2-cyano-3-(1H-indol-3-yl)-pent-2-enedinitrile or ethyl-2,4-dicyano-3-(1H-indol-3-yl)but-2-enoate derivative with an aryl aldehyde and a 6-aminouracil derivative. The indole derivatives were prepared by the reaction of the corresponding 3-(cyanoacetyl)indoles with acetonitrile derivatives.

Key words

multicomponent reactions - naphthyridines - pyrimidines - heterocycles - polycycles - cyclizations

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