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Synthesis 2015; 47(06): 827-835
DOI: 10.1055/s-0034-1379696
DOI: 10.1055/s-0034-1379696
paper
Efficient Syntheses of Ethyl 2-Methylthio- and Ethyl 2-Benzylthio-6-methyl(aryl)pyrimidine-4-carboxylates and Their Carboxylic Acid Derivatives
Further Information
Publication History
Received: 15 October 2014
Accepted after revision: 17 November 2014
Publication Date:
05 January 2015 (online)
Abstract
A simple and efficient procedure for the synthesis of ethyl 2-methylthio- and ethyl 2-benzylthio-6-methyl(aryl)-pyrimidine-4-carboxylates and their corresponding acid derivatives is reported. The products are obtained in good yields via the cyclocondensation reaction of ethyl 4-alkoxy-2-oxo-4-methyl(aryl)-but-3-enoates with 2-methylisothiourea sulfate or 2-benzylisothiourea hydrochloride, under mild, basic, aqueous conditions.
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