β-Trifluoromethyl-α,β-unsaturated Ketones

Introduction

β-Trifluoromethyl enones are important synthetic precursors of molecules containing chiral centers with a trifluoromethyl substituent, a structural motif which is present in biologically active compounds, chiral reagents and in materials for optoelectronic devices.[1] The presence of the strong electron-withdrawing β-trifluoromethyl group increases the electrophilicity of the double bond expediting the conjugate nucleophilic additions.

• References

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