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Synthesis 2015; 47(06): 854-860
DOI: 10.1055/s-0034-1379942
DOI: 10.1055/s-0034-1379942
paper
Synthesis of Aryl Fluorides from Potassium Aryltrifluoroborates and Selectfluor® Mediated by Iron(III) Chloride
Weitere Informationen
Publikationsverlauf
Received: 07. Oktober 2014
Accepted after revision: 02. Dezember 2014
Publikationsdatum:
07. Januar 2015 (online)
Dedicated to Prof. Paul Knochel on the occasion of his 59th birthday
Abstract
The synthesis of fluorinated arenes by the iron-mediated fluorination of potassium aryltrifluoroborates with Selectfluor® and potassium fluoride is described. The fluorination reaction uses commercially available reagents and without requiring the addition of exogenous ligands. Fluorinated compounds were obtained in moderate to good yields under mild reaction conditions.
Key words
fluorination - aryl fluorides - potassium aryltrifluoroborates - iron - Selectfluor® - potassium fluorideSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1379942.
- Supporting Information
-
References
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Copper-mediated electrophilic fluorination:
There are some examples of not fully ipso-regioselective reactions of arylborates with electrophiles are reported, see: