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Synthesis 2015; 47(06): 875-886
DOI: 10.1055/s-0034-1379956
DOI: 10.1055/s-0034-1379956
paper
Asymmetric Organocatalytic Aza-Michael Reactions of Isatin Derivatives
Further Information
Publication History
Received: 05 November 2014
Accepted after revision: 05 December 2014
Publication Date:
14 January 2015 (online)
Abstract
Isatin was activated by derivatization to a Schiff base with aniline and used as an aza-Michael donor in organocatalytic asymmetric reactions with symmetric and nonsymmetric unsaturated 1,4-diketones. After hydrolysis (in situ), the N-substituted isatins were obtained in high yields (up to >95%) with high enantioselectivity (up to 95%).
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1379956.
- Supporting Information
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