Disulfonimide-Catalyzed Asymmetric Synthesis of δ-Amino-β-Keto Esters

Abstract

A chiral disulfonimide-catalyzed asymmetric synthesis of δ-amino-β-keto esters via a vinylogous Mukaiyama–Mannich reaction of the Chan diene with N-Boc imines has been developed. The desired products were obtained in good to excellent yields and enantioselectivities.

Key words

chiral disulfonimides - δ-amino-β-keto esters - Chan diene - N-Boc imines - vinylogous Mukaiyama–Mannich reaction

• References and Notes

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