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DOI: 10.1055/s-0034-1380114
Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known N-Methyl-d-aspartate Receptor Allosteric Modulators
Publication History
Received: 14 November 2014
Accepted after revision: 22 December 2014
Publication Date:
19 March 2015 (online)
![](https://www.thieme-connect.de/media/synthesis/201511/lookinside/thumbnails/ss-2014-t0697-op_10-1055_s-0034-1380114-1.jpg)
Abstract
9-Substituted phenanthrene-3-carboxylic acids have been reported to have allosteric modulatory activity at the N-methyl-d-aspartate (NMDA) receptor. This receptor is activated by the excitatory neurotransmitter l-glutamate and has been implicated in a range of neurological disorders such as schizophrenia, epilepsy and chronic pain, and in neurodegenerative disorders such as Alzheimer’s disease. Herein, the convenient synthesis of a wide range of novel 3,9-disubstituted phenanthrene derivatives starting from a few common intermediates is described. These new phenanthrene derivatives will help to clarify the structural requirements for allosteric modulation of the NMDA receptor.
Key words
phenanthrenes - NMDA receptor - allosteric modulators - palladium coupling - Wittig reactionSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034–1380114.
- Supporting Information
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References
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