An Organocatalytic Access to Spiro[4.5]decanes and Spiro[4.6]undecanes Containing Aminolactones and 3-Aminopyrrolidines

Abstract

The organocatalyzed Mannich coupling of cyclic carboxaldehydes allowed the concise and simple preparation of spirocyclic aminolactones. Their conversion into pharmaceutically relevant spiro[4.5]cyclic and spiro[4.6]cyclic 3-aminopyrrolidines is also described.

Key words

Mannich reaction - spiro[4.5]decanes - spiro[4.6]undecanes - aminolactones - 3-aminopyrrolidines

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