Synthesis, Table of Contents Synthesis 2015; 47(12): 1775-1779DOI: 10.1055/s-0034-1380147 paper © Georg Thieme Verlag Stuttgart · New York An Unsymmetrical Iron Catalyst for the Asymmetric Transfer Hydrogenation of Ketones Samantha A. M. Smith Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada Email: robert.morris@utoronto.ca , Robert H. Morris* Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada Email: robert.morris@utoronto.ca › Author Affiliations Recommend Article Abstract Buy Article All articles of this category Abstract A new iron(II)(Ph2P–NH–N–PCy2) complex with a dicyclohexylphosphino group trans to the NH group was found to catalyze the asymmetric transfer hydrogenation of a variety of ketones with high enantioselectivity. Key words Key wordshydrogenation - iron catalysis - chirality - ketones - alcohols Full Text References References 1a Knowles WS, Noyori R. Acc. Chem. Res. 2007; 40: 1238 1b Dupau P. Top. Organomet. Chem. 2012; 42: 47 1c Saudan LA. Acc. Chem. Res. 2007; 40: 1309 1d Noyori R. Adv. Synth. Catal. 2003; 345: 15 1e Noyori R, Ohkuma T. Angew. Chem. Int. Ed. 2001; 40: 40 2 Morris RH. Chem. Soc. Rev. 2009; 38: 2282 3a Chen JS, Chen LL, Xing Y, Chen G, Shen WY, Dong ZR, Li YY, Gao JX. Acta Chim. Sin. 2004; 62: 1745 3b Sui-Seng C, Freutel F, Lough AJ, Morris RH. Angew. Chem. Int. Ed. 2008; 47: 940 3c Mikhailine AA, Lough AJ, Morris RH. J. Am. Chem. Soc. 2009; 131: 1394 3d Meyer N, Lough AJ, Morris RH. Chem. Eur. J. 2009; 15: 5605 3e Zhou S, Fleischer S, Junge K, Das S, Addis D, Beller M. Angew. Chem. Int. Ed. 2010; 49: 8121 3f Lagaditis PO, Lough AJ, Morris RH. J. Am. Chem. Soc. 2011; 133: 9662 3g Sues PE, Lough AJ, Morris RH. Organometallics 2011; 30: 4418 3h Yu S, Shen W, Li Y, Dong Z, Xu Y, Li Q, Zhang J, Gao J. Adv. Synth. Catal. 2012; 354: 818 3i Mikhailine AA, Maishan MI, Lough AJ, Morris RH. J. Am. Chem. Soc. 2012; 134: 12266 3j Mikhailine AA, Maishan MI, Morris RH. Org. Lett. 2012; 14: 4638 3k Prokopchuk DE, Morris RH. Organometallics 2012; 31: 7375 3l Sonnenberg JF, Coombs N, Dube PA, Morris RH. J. Am. Chem. Soc. 2012; 134: 5893 3m Zuo W, Li Y, Lough AJ, Morris RH. Science 2013; 342: 1080 3n Sues PE, Demmans KZ, Morris RH. Dalton Trans. 2014; 43: 7650 4a Berkessel A, Reichau S, von der Hoh A, Leconte N, Neudorfl JM. Organometallics 2011; 30: 3880 4b Fleischer S, Werkmeister S, Zhou SL, Junge K, Beller M. Chem. Eur. J. 2012; 18: 9005 4c Fleischer S, Zhou SL, Werkmeister S, Junge K, Beller M. Chem. Eur. J. 2013; 19: 4997 4d Li Y, Yu S, Wu X, Xiao J, Shen W, Dong Z, Gao J. J. Am. Chem. Soc. 2014; 136: 4031 4e Lagaditis PO, Sues PE, Sonnenberg JF, Wan KY, Lough AJ, Morris RH. J. Am. Chem. Soc. 2014; 136: 1367 4f Zuo W, Tauer S, Prokopchuk DE, Morris RH. Organometallics 2014; 33: 5791 5 Xu Y, Docherty GF, Woodward G, Wills M. Tetrahedron: Asymmetry 2006; 17: 2925 6 Brands KM. J, Payack JF, Rosen JD, Nelson TD, Candelario A, Huffman MA, Zhao MM, Li J, Craig B, Song ZJ, Tschaen DM, Hansen K, Devine PN, Pye PJ, Rossen K, Dormer PG, Reamer RA, Welch CJ, Mathre DJ, Tsou NN, McNamara JM, Reider PJ. J. Am. Chem. Soc. 2003; 125: 2129 Supplementary Material Supplementary Material Supporting Information
