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Synthesis 2015; 47(14): 2093-2099
DOI: 10.1055/s-0034-1380201
DOI: 10.1055/s-0034-1380201
paper
Alkylative Amination of Biogenic Furans through Imine-to-Azaallyl Anion Umpolung
Further Information
Publication History
Received: 03 February 2015
Accepted after revision: 20 March 2015
Publication Date:
19 May 2015 (online)
Abstract
Starting from biogenic furfurals, an operationally simple and scalable condensation-umpolung-alkylation protocol was employed in the synthesis of racemic furfurylamines. Subsequent enzymatic kinetic resolution by ω-transaminase or lipase biocatalysts allows for the preparation of functionalized heterocyclic building blocks from biogenic base chemicals in optically pure form.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380201.
- Supporting Information
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