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Synthesis 2015; 47(14): 2073-2080
DOI: 10.1055/s-0034-1380204
DOI: 10.1055/s-0034-1380204
paper
Synthesis of Trifluoromethylated Tetrahydrochromeno[2,3-c]pyrazol-5(1H)-ones via a One-Pot Multicomponent Reaction in the Presence of 4-Toluenesulfonic Acid
Further Information
Publication History
Received: 10 February 2015
Accepted after revision: 22 March 2015
Publication Date:
30 April 2015 (online)
Abstract
An efficient one-pot multicomponent synthesis of trifluoromethylated tetrahydrochromeno[2,3-c]pyrazol-5(1H)-one derivatives by the reaction of an aromatic aldehyde, a cyclohexane-1,3-dione, and 2-phenyl-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one in the presence of 4-toluenesulfonic acid is described; the reaction has good yields and good functional group tolerance. 4-Toluenesulfonic acid plays a dual role as both catalyst and dehydrating agent in the conversion. In addition, a possible mechanism for the reaction is proposed.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380204.
- Supporting Information
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