A Convenient Synthesis of N,N-Dimethylformamidines from Sulfonamides

Abstract

N,N-Dimethylformamidines were synthesized from sulfonamides using the Vilsmeier reagent as a cleavage activator. The reactions were performed under mild conditions achieving good to excellent yields. The chemistry presented can also be used as a deprotection strategy when amines or anilines are protected with sulfonyl groups, such as the tosyl group.

Key words

sulfonamides - cleavage - imines - nucleophilic addition - amines - hydrolysis

• References

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