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Synthesis 2015; 47(15): 2233-2241
DOI: 10.1055/s-0034-1380525
DOI: 10.1055/s-0034-1380525
special topic
Metal-Free Conjugate Addition of Alkenylboronic Acids to Enedicarbonyl Compounds towards the Synthesis of Pyridazine Derivatives
Further Information
Publication History
Received: 04 March 2015
Accepted: 12 March 2015
Publication Date:
16 April 2015 (online)
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Abstract
The regioselective conjugate addition of alkenylboronic acids to electronically-differentiated 1,4-enedicarbonyl compounds under metal-free conditions, using tartaric acid as promoter of the reaction is reported. The resulting compounds have been used as starting materials in the synthesis of 4-alkenyl-4,5-dihydropyridazin-3(2H)-ones or 4-alkylpyridazin-3(2H)-ones by reaction with hydrazine hydrate and acetic acid.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380525.
- Supporting Information
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