Chiral Primary Amine Catalyzed Asymmetric Tandem Reduction–Michael Addition–Protonation Reaction between Alkylidene Meldrum’s Acid and α-Substituted Vinyl Ketones

Abstract

One-pot three-component tandem reduction–Michael addition–protonation reactions of alkylidene Meldrum’s acids to α-substituted vinyl ketones have been developed by using a chiral primary amine as the organocatalyst, affording the products in excellent yields and with good enantioselectivity.

Key words

primary amine catalysis - enamine protonation - Meldrum’s acid - Michael addition - α-substituted vinyl ketone

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