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Synthesis 2015; 47(16): 2385-2390
DOI: 10.1055/s-0034-1380719
DOI: 10.1055/s-0034-1380719
special topic
Toward a Green Atom Economy: Development of a Sustainable Multicomponent Reaction
Further Information
Publication History
Received: 19 March 2015
Accepted after revision: 13 April 2015
Publication Date:
26 May 2015 (online)
Abstract
The recently discovered photoinduced three-component reaction of diazo ketones, carboxylic acids, and isocyanides can be efficiently performed under continuous-flow conditions with consequential advantages in terms of selectivity and productivity. The investigation of the flow process and the determination of its sustainability are discussed in detail. This multicomponent reaction affords stereodefined captodative olefins, useful as synthons in organic chemistry.
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