Palladium-Catalyzed Carbonylative Synthesis of N-Benzoylindoles with Mo(CO)₆ as the Carbon Monoxide Source

Abstract

A mild and carbon monoxide gas-free palladium-catalyzed aminocarbonylation of indole has been developed for the synthesis of N-benzoylindoles. This method uses Mo(CO)₆ as a convenient CO-precursor and BuPAd₂ as the ligand. A number of substituents on the aryl bromide species is tolerated under the presented conditions and gave the desired products in up to excellent yields.

Key words

benzoylindole - aminocarbonylation - palladium catalyst - molybdenum hexacarbonyl - indole

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