A Metal-Free Approach to Carboxylic Acids by Oxidation of Alkyl, Aryl, or Heteroaryl Alkyl Ketones or Arylalkynes

K. A. Aravinda Kumar; Vunnam Venkateswarlu; Ram A. Vishwakarma; Sanghapal D. Sawant

doi:10.1055/s-0034-1381026

Synthesis, Table of Contents

Synthesis 2015; 47(20): 3161-3168
DOI: 10.1055/s-0034-1381026

paper

A Metal-Free Approach to Carboxylic Acids by Oxidation of Alkyl, Aryl, or Heteroaryl Alkyl Ketones or Arylalkynes

K. A. Aravinda Kumar

^aMedicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180 001, India

,

Vunnam Venkateswarlu

^aMedicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180 001, India

^bAcademy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India Email: sdsawant@iiim.res.in Email: sawant.rrl@gmail.com

,

Ram A. Vishwakarma

^aMedicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180 001, India

^bAcademy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India Email: sdsawant@iiim.res.in Email: sawant.rrl@gmail.com

,

Sanghapal D. Sawant*

^aMedicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180 001, India

^bAcademy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India Email: sdsawant@iiim.res.in Email: sawant.rrl@gmail.com

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Abstract

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Abstract

The metal-free oxidation of dialkyl, alkyl aryl, or alkyl heteroaryl ketones or arylalkynes to the corresponding carboxylic acids is achieved using an oxidative mixture of Oxone and trifluoroacetic acid. This green method is a simple and mild protocol to obtain carboxylic derivatives in excellent yields.

Key words

ketones - alkynes - oxidation - carboxylic acids - green chemistry

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References

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