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Planta Med 2014; 80(12): 1017-1022
DOI: 10.1055/s-0034-1382903
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Dysoxydensins A–G, Seven New Clerodane Diterpenoids from Dysoxylum densiflorum

Ji Gu   *
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2   Yuxi China Tobacco Seed Co., Ltd., Yuxi, P. R. China
,
Gui-Guang Cheng   *
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Sheng-Yan Qian
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Yan Li
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Ya-Ping Liu
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Xiao-Dong Luo
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
› Author Affiliations
Further Information

Publication History

received 01 April 2014
revised 17 June 2014

accepted 23 June 2014

Publication Date:
06 August 2014 (online)

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Abstract

Seven new clerodane diterpenoids, dysoxydensins A–G (1–7), together with six known clerodanes, were isolated from Dysoxylum densiflorum. The structures of all the compounds were elucidated by extensive spectroscopic analysis. These compounds were evaluated for their cytotoxic activities against five human cancer cell lines, and compounds 2, 3, and 5 showed moderate cytotoxic activities.

Key words

clerodanes - cytotoxic activities - Dysoxylum densiflorum - Meliaceae

* These authors contributed equally to this work.


Supporting Information

 

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