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Planta Med 2014; 80(13): 1079-1087
DOI: 10.1055/s-0034-1382957
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Chemical Composition and Biological Effects of Artemisia maritima and Artemisia nilagirica Essential Oils from Wild Plants of Western Himalaya

Iris Stappen
1   Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria
,
Jürgen Wanner
2   Kurt Kitzing Co., Wallerstein, Germany
,
Nurhayat Tabanca
3   National Center for Natural Products Research, University of Mississippi, University, MS, USA
,
David E. Wedge
4   US Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, University of Mississippi, University, MS, USA
,
Abbas Ali
3   National Center for Natural Products Research, University of Mississippi, University, MS, USA
,
Ikhlas A. Khan
3   National Center for Natural Products Research, University of Mississippi, University, MS, USA
5   Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS, USA
,
Vijay K. Kaul
6   CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
,
Brij Lal
7   Biodiversity Division, Institute of Himalayan Bioresource Technology, Palampur, India
,
Vikas Jaitak
7   Biodiversity Division, Institute of Himalayan Bioresource Technology, Palampur, India
8   Centre for Chemical and Pharmaceutical Sciences, Central University of Punjab, Bathinda, India
,
Velizar Gochev
9   Department of Biochemistry and Microbiology, “Paisii Hilendarski” – University of Plovdiv, Plovdiv, Bulgaria
,
Tania Girova
9   Department of Biochemistry and Microbiology, “Paisii Hilendarski” – University of Plovdiv, Plovdiv, Bulgaria
,
Albena Stoyanova
10   Department of Essential Oils, University of Food Technologies, Plovdiv, Bulgaria
,
Erich Schmidt
1   Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria
,
Leopold Jirovetz
1   Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria
› Author Affiliations
Further Information

Publication History

received 11 December 2013
revised 11 July 2014

accepted 13 July 2014

Publication Date:
15 August 2014 (online)

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Chemical Composition and Biological Effects of Artemisia maritima and Artemisia nilagirica Essential Oils from Wild Plants of Western HimalayaPlanta Med 2014; 80(13): E2-E2
DOI: 10.1055/s-0034-1383036

Abstract

Artemisia species possess pharmacological properties that are used for medical purposes worldwide. In this paper, the essential oils from the aerial parts of Artemisia nilagirica and Artemisia maritima from the western Indian Himalaya region are described. The main compounds analyzed by simultaneous GC/MS and GC/FID were camphor and 1,8-cineole from A. maritima, and camphor and artemisia ketone from A. nilagirica. Additionally, the oils were evaluated for their antibacterial, antifungal, mosquito biting deterrent, and larvicidal activities. A. nilagirica essential oil demonstrated nonselective antifungal activity against plant pathogens Colletotrichum acutatum, Colletotrichum fragariae, and Colletotrichum gloeosporioides, whereas A. maritima did not show antifungal activity. Both Artemisia spp. exhibited considerable mosquito biting deterrence, whereas only A. nilagirica showed larvicidal activity against Aedes aegypti. Antibacterial effects assessed by an agar dilution assay demonstrated greater activity of A. maritima essential oil against Staphylococcus aureus and Pseudomonas aeruginosa compared to A. nilagirica.

Key words

Artemisia nilagirica - Artemisia maritima - Asteraceae - antifungal activity - antibacterial activity - biting deterrence - larvicidal activity
 

  • References

  • 1 Rani PN, Moorthi C, Senthamarai R, Kathiresan K. A study to explore the pharmacognostic and phytochemical screening of Artemisia nilagirica leaves found in Nilgiris district of Tamil Nadu. Int J Pharm Sci 2012; 4: 441-447
    PubMedSearch in Google Scholar
  • 2 Haider F, Kumar N, Naqvi A, Das Bagchi G. Oil constituents of Artemisia nilagirica var. septentrionalis during different growth phases at subtropical conditions of North Indian plains. J Essent Oil Res 2007; 19: 5-7
    CrossrefPubMedSearch in Google Scholar
  • 3 Badoni R, Semwal DK, Rewat U. Altitudinal variation in the volatile constituents of Artemisia nilagirica . Int J Ess Oil Therapeutics 2009; 3: 66-68
    PubMedSearch in Google Scholar
  • 4 Haider F, Kumar N, Naqvi A, Das Bagchi G. Oil constituents of Artemisia nilagirica var. septentrionalis growing at different altitudes. Nat Prod Commun 2010; 5: 1959-1960
    PubMedSearch in Google Scholar
  • 5 Leeja L, Thoppil JE. Essential oil composition and mosquito larvicidal activity of Artemisia nilagirica (C.B. Clarke) Pampan. from South India. J Phytol Res 2004; 17: 155-158
    PubMedSearch in Google Scholar
  • 6 Shafi PM, Nambiar MKG, Clery RA, Sarma YR, Veena SS. Composition and antifungal activity of the oil of Artemisia nilagirica (Clarke) Pamp. J Ess Oil Res 2004; 16: 377-379
    CrossrefPubMedSearch in Google Scholar
  • 7 Kishore A, Dubey NK, Chansouria JPN. Antimycotic activity of the essential oil of Artemisia nilagirica . Flavour Fragr J 2001; 16: 61-63
    CrossrefPubMedSearch in Google Scholar
  • 8 Vijayalakshmi A, Rakesh T, Ravichandiran V. Characterization and evaluation of antidermatophytic activity of the essential oil from Artemisia nilagirica leaves growing wild in Nilgiris. Int J Pharm Sci 2010; 2: 93-97
    PubMedSearch in Google Scholar
  • 9 Sati SC, Sati N, Ahluwalia V, Walia S, Sati OP. Chemical composition and antifungal activity of Artemisia nilagirica essential oil growing in northern hilly areas of India. Nat Prod Res 2013; 27: 445-448
    PubMedSearch in Google Scholar
  • 10 Kumar E, Bath ZA, Kumar V, Zargar MI. A short review on Artemisia maritima Linn. Int J Res Phytochem Pharmacol 2011; 1: 201-206
    PubMedSearch in Google Scholar
  • 11 Shah AJ, Gilani AH, Abbas K, Rasheed M, Ahmed A, Ahmed VU. Studies on the chemical composition and possible mechanisms underlying the antispasmodic and bronchodilatory activities of the essential oil of Artemisia maritima L. Arch Pharm Res 2011; 34: 1227-1238
    CrossrefPubMedSearch in Google Scholar
  • 12 Ashraf M, Hayat MQ, Jabeen S, Shaheen N, Khan MA, Yasmin G. Artemisia L. species recognized by the local community of northern areas of Pakistan as folk therapeutic plants. J Med Plants Res 2010; 4: 112-119
    PubMedSearch in Google Scholar
  • 13 Mathela CS, Kharkwal H, Shah GC. Essential oil composition of some Himalayan Artemisia species. J Ess Oil Res 1994; 6: 345-348
    CrossrefPubMedSearch in Google Scholar
  • 14 Khan SM, Harper DM, Page S, Ahmad H. Residual value analyses of the medicinal flora of the Western Himalayas: the Naran valley, Pakistan. Pak J Bot 2011; 43: 97-103
    PubMedSearch in Google Scholar
  • 15 Gilani SS, Abbas SQ, Shinwari ZK, Hussain F, Nargis K. Ethnobotanical studies of Kurram Agency, Pakistan through rural community participation. Pak J Biol Sci 2003; 6: 1368-1375
    CrossrefPubMedSearch in Google Scholar
  • 16 Inouye S, Amano M, Abe S, Amin M, Karim F. Volatile aroma constituents to twenty herbs growing wild in Karakoram/Himalaya in Pakistan (1). Aroma Res 2006; 7: 354-361
    PubMedSearch in Google Scholar
  • 17 Inouye S, Uchida K, Abe S. Antimicrobial activity, especially anti-Trichophyton vapor activity of twenty herbs growing wild in the Karakoram (Pakistan Himalayas). Aroma Res 2007; 8: 282-288
    PubMedSearch in Google Scholar
  • 18 Hethelyi E, Eseko I, Grosz M, Gergel M, Palinkas J. Capillary GC analysis of Artemisia essential oils. Kozmetika 1995; 44: 117-120
    PubMedSearch in Google Scholar
  • 19 Sah S, Lohani H, Narayan O, Bartwal S, Chauhan NK. Volatile constituents of Artemisia maritima Linn. grown in Garhwal Himalaya. J Ess Oil Bear Plants 2010; 13: 603-606
    PubMedSearch in Google Scholar
  • 20 Jaitak V, Singh B, Kaul VK. Variability of volatile constituents in Artemisia maritima in western Himalaya. Nat Prod Res 2008; 22: 565-568
    CrossrefPubMedSearch in Google Scholar
  • 21 Sati SC, Sati N, Ahluwalia V, Walia S, Sati OP. Chemical composition and antifungal activity of Artemisia nilagirica essential oil growing in northern hilly areas of India. Nat Prod Res 2013; 27: 45-48
    CrossrefPubMedSearch in Google Scholar
  • 22 Ahameethunisa AR, Hopper W. Antibacterial activity of Artemisia nilagirica leaf extracts against clinical and phytopathogenic bacteria. BMC Complement Alternat Med 2010; 10: 6
    CrossrefPubMedSearch in Google Scholar
  • 23 Cha JD, Jeong MR, Jeong SI, Moon SI, Kim JY, Kil BS, Song YH. Antimicrobial activity of the essential oils of Artemisia scoparia and A. capillaris . Planta Med 2005; 71: 186-190
    Thieme ConnectPubMedSearch in Google Scholar
  • 24 Kazemi M, Dakhili M, Davari M. Constituents and antimicrobial activity of essential oil of Artemisia lehmanniana Bunge from Iran. J Ess Oil Bear Plants 2011; 15: 392-398
    PubMedSearch in Google Scholar
  • 25 Kazemi M, Dakhili M, Dadkhah A, Yasrebifar Z, Lafijani K. Composition, antimicrobial and antioxidant activities of the essential oil of Artemisia kermanensis Podl., an endemic species from Iran. J Med Plant Res 2011; 5: 4993-4998
    PubMedSearch in Google Scholar
  • 26 Zhang J, Shi B, Gao P, Wang J, Wu W. Composition, in vitro antioxidant and antimicrobial activity of the essential oils from Artemisia lavandulaefolia DC. J Med Plant Res 2012; 6: 1284-1288
    PubMedSearch in Google Scholar
  • 27 Tzakou O, Pitarokili D, Chinou IB, Harvala C. Composition and antimicrobial activity of the essential oil of Salvia ringens . Planta Med 2001; 67: 81-83
    Thieme ConnectPubMedSearch in Google Scholar
  • 28 Gupta N, Saxena G, Kalra SS. Antimicrobial activity pattern of certain terpenoids. IJPBS 2011; 2: 87-91
    PubMedSearch in Google Scholar
  • 29 Klein G, Rüben C, Upmann M. Antimicrobial activity of essential oil components against potential food spoilage microorganisms. Curr Microbiol 2013; 67: 200-208
    CrossrefPubMedSearch in Google Scholar
  • 30 Panneerselvam C, Murugan K, Kovendan K, Mahesh KP. Mosquito larvicidal, pupicidal, adulticidal and repellent activity of Artemisia nilagirica (Famils: Dompositae) against Anopheles stephensi and Aedes aegypti . Parasitol Res 2012; 111: 2241-2251
    CrossrefPubMedSearch in Google Scholar
  • 31 Wedge DE, Nagle DG. A new 2D-TLC bioautography method for the discovery of novel antifungal agents to control plant pathogens. J Nat Prod 2000; 63: 1050-1054
    CrossrefPubMedSearch in Google Scholar
  • 32 Kumar R, Dubey NK, Tiwari OP, Tripathi YB, Sinha KK. Evaluation of some essential oils as botanical fungitoxicants for the protection of stored food commodities from fungal infestation. J Sci Food Agric 2007; 87: 1737-1742
    CrossrefPubMedSearch in Google Scholar
  • 33 Kumar R, Mishra SK, Dubey NK, Tripathi YB. Evaluation of Chenopodium ambrosioides oil as a potential source of antifungal, antiaflatoxigenic and antioxidant activity. Int J Food Microbiol 2007; 115: 159-164
    CrossrefPubMedSearch in Google Scholar
  • 34 Sharma PK, Raina AP, Dureja P. Evaluation of the antifungal and phytotoxic effects of various essential oils against Sclerotin rolfsii (Sacc) and Rhizoctonia bataticola (Taub). Arch Phytopath Plant Protect 2009; 42: 65-72
    PubMedSearch in Google Scholar
  • 35 Singh N, Kaul VK, Megeji NW, Singh V, Shuja PS. Essential oil composition of three accessions of Dracocephalum heterophyllum Benth. cultivated at Palampur, India. NPC 2008; 22: 927-936
    PubMedSearch in Google Scholar
  • 36 Schmidt E. Production of essential oils. In: Baser KH, Buchbauer G, editors Handbook of essential oils. Boca Raton: CRC Press; 2010: 89-90
    Search in Google Scholar
  • 37 Nemeth E, Bernáth J, Tarján G. Quantitative and qualitative studies of essential oils of Hungarian Achillea populations. JHSMP 2007; 13: 57-69
    PubMedSearch in Google Scholar
  • 38 Adams RP. Identification of essential oil components by gas chromatography/quadrupole mass spectrometry. Carol Stream: Allured Publishing; 2007
    Search in Google Scholar
  • 39 Joulain D, Koenig WA. The atlas of spectral data of sesquiterpene hydrocarbons. Hamburg: EB Verlag; 2008
    Search in Google Scholar
  • 40 Heller SR, Milne GWA. EPA/NIH mass spectral data base. Washington DC: US Government Printing Office; 1978; 1980: 1983
    PubMedSearch in Google Scholar
  • 41 Stenhagen E, Abrahamsson S, McLafferty FW. Registry of mass spectral data. New York: Wiley; 1974
    Search in Google Scholar
  • 42 Swigar AA, Siverstein RM. Monoterpenes. Milwaukee: Aldrich Chemical Co.; 1981
    Search in Google Scholar
  • 43 Clinical and Laboratory Standards Institute. Method for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; CLSI approved standard document M7-A7, 7th edition. Wayne: CLSI; 2006
    Search in Google Scholar
  • 44 Clinical and Laboratory Standards Institute. Reference method for broth dilution antifungal susceptibility testing of yeasts: CLSI approved standard M27-A3. 3rd. edition. Wayne: CLSI; 2008
    Search in Google Scholar
  • 45 Smith BJ, Black LL. Morphological, cultural, and pathogenic variation among Colletotrichum species isolated from strawberry. Plant Dis 1990; 74: 69-76
    CrossrefPubMedSearch in Google Scholar
  • 46 Pridgeon JW, Meepagala KM, Becnel JJ, Clark GG, Pereira RM, Linthicum KJ. Structure-activity relationships of 33 piperidines as toxicants against female adults of Aedes aegypti (Diptera: Culicidae). J Med Entomol 2007; 44: 263-269
    PubMedSearch in Google Scholar
  • 47 Klun JA, Kramer M, Debboun M. A new in vitro bioassay system for discovery of novel human-use mosquito repellents. J Am Mosq Control Assoc 2005; 21: 64-70
    CrossrefPubMedSearch in Google Scholar
  • 48 Ali A, Cantrell CL, Bernier UR, Duke SO, Schneider JC, Khan I. Aedes aegypti (Diptera: Culicidae) biting deterrence: structure-activity relationship of saturated and unsaturated fatty acids. J Med Entomol 2012; 49: 1370-1378
    CrossrefPubMedSearch in Google Scholar
  • 49 Pridgeon JW, Becnel JJ, Clark GG, Linthicum KJ. A high throughput screening method to identify potential pesticides for mosquito control. J Med Entomol 2009; 46: 335-341
    CrossrefPubMedSearch in Google Scholar