Planta Med 2014; 80(13): 1079-1087
DOI: 10.1055/s-0034-1382957
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Chemical Composition and Biological Effects of Artemisia maritima and Artemisia nilagirica Essential Oils from Wild Plants of Western Himalaya

Iris Stappen
1   Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria
,
Jürgen Wanner
2   Kurt Kitzing Co., Wallerstein, Germany
,
Nurhayat Tabanca
3   National Center for Natural Products Research, University of Mississippi, University, MS, USA
,
David E. Wedge
4   US Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, University of Mississippi, University, MS, USA
,
Abbas Ali
3   National Center for Natural Products Research, University of Mississippi, University, MS, USA
,
Ikhlas A. Khan
3   National Center for Natural Products Research, University of Mississippi, University, MS, USA
5   Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS, USA
,
Vijay K. Kaul
6   CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
,
Brij Lal
7   Biodiversity Division, Institute of Himalayan Bioresource Technology, Palampur, India
,
Vikas Jaitak
7   Biodiversity Division, Institute of Himalayan Bioresource Technology, Palampur, India
8   Centre for Chemical and Pharmaceutical Sciences, Central University of Punjab, Bathinda, India
,
Velizar Gochev
9   Department of Biochemistry and Microbiology, “Paisii Hilendarski” – University of Plovdiv, Plovdiv, Bulgaria
,
Tania Girova
9   Department of Biochemistry and Microbiology, “Paisii Hilendarski” – University of Plovdiv, Plovdiv, Bulgaria
,
Albena Stoyanova
10   Department of Essential Oils, University of Food Technologies, Plovdiv, Bulgaria
,
Erich Schmidt
1   Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria
,
Leopold Jirovetz
1   Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 11. Dezember 2013
revised 11. Juli 2014

accepted 13. Juli 2014

Publikationsdatum:
15. August 2014 (online)

Abstract

Artemisia species possess pharmacological properties that are used for medical purposes worldwide. In this paper, the essential oils from the aerial parts of Artemisia nilagirica and Artemisia maritima from the western Indian Himalaya region are described. The main compounds analyzed by simultaneous GC/MS and GC/FID were camphor and 1,8-cineole from A. maritima, and camphor and artemisia ketone from A. nilagirica. Additionally, the oils were evaluated for their antibacterial, antifungal, mosquito biting deterrent, and larvicidal activities. A. nilagirica essential oil demonstrated nonselective antifungal activity against plant pathogens Colletotrichum acutatum, Colletotrichum fragariae, and Colletotrichum gloeosporioides, whereas A. maritima did not show antifungal activity. Both Artemisia spp. exhibited considerable mosquito biting deterrence, whereas only A. nilagirica showed larvicidal activity against Aedes aegypti. Antibacterial effects assessed by an agar dilution assay demonstrated greater activity of A. maritima essential oil against Staphylococcus aureus and Pseudomonas aeruginosa compared to A. nilagirica.

 
  • References

  • 1 Rani PN, Moorthi C, Senthamarai R, Kathiresan K. A study to explore the pharmacognostic and phytochemical screening of Artemisia nilagirica leaves found in Nilgiris district of Tamil Nadu. Int J Pharm Sci 2012; 4: 441-447
  • 2 Haider F, Kumar N, Naqvi A, Das Bagchi G. Oil constituents of Artemisia nilagirica var. septentrionalis during different growth phases at subtropical conditions of North Indian plains. J Essent Oil Res 2007; 19: 5-7
  • 3 Badoni R, Semwal DK, Rewat U. Altitudinal variation in the volatile constituents of Artemisia nilagirica . Int J Ess Oil Therapeutics 2009; 3: 66-68
  • 4 Haider F, Kumar N, Naqvi A, Das Bagchi G. Oil constituents of Artemisia nilagirica var. septentrionalis growing at different altitudes. Nat Prod Commun 2010; 5: 1959-1960
  • 5 Leeja L, Thoppil JE. Essential oil composition and mosquito larvicidal activity of Artemisia nilagirica (C.B. Clarke) Pampan. from South India. J Phytol Res 2004; 17: 155-158
  • 6 Shafi PM, Nambiar MKG, Clery RA, Sarma YR, Veena SS. Composition and antifungal activity of the oil of Artemisia nilagirica (Clarke) Pamp. J Ess Oil Res 2004; 16: 377-379
  • 7 Kishore A, Dubey NK, Chansouria JPN. Antimycotic activity of the essential oil of Artemisia nilagirica . Flavour Fragr J 2001; 16: 61-63
  • 8 Vijayalakshmi A, Rakesh T, Ravichandiran V. Characterization and evaluation of antidermatophytic activity of the essential oil from Artemisia nilagirica leaves growing wild in Nilgiris. Int J Pharm Sci 2010; 2: 93-97
  • 9 Sati SC, Sati N, Ahluwalia V, Walia S, Sati OP. Chemical composition and antifungal activity of Artemisia nilagirica essential oil growing in northern hilly areas of India. Nat Prod Res 2013; 27: 445-448
  • 10 Kumar E, Bath ZA, Kumar V, Zargar MI. A short review on Artemisia maritima Linn. Int J Res Phytochem Pharmacol 2011; 1: 201-206
  • 11 Shah AJ, Gilani AH, Abbas K, Rasheed M, Ahmed A, Ahmed VU. Studies on the chemical composition and possible mechanisms underlying the antispasmodic and bronchodilatory activities of the essential oil of Artemisia maritima L. Arch Pharm Res 2011; 34: 1227-1238
  • 12 Ashraf M, Hayat MQ, Jabeen S, Shaheen N, Khan MA, Yasmin G. Artemisia L. species recognized by the local community of northern areas of Pakistan as folk therapeutic plants. J Med Plants Res 2010; 4: 112-119
  • 13 Mathela CS, Kharkwal H, Shah GC. Essential oil composition of some Himalayan Artemisia species. J Ess Oil Res 1994; 6: 345-348
  • 14 Khan SM, Harper DM, Page S, Ahmad H. Residual value analyses of the medicinal flora of the Western Himalayas: the Naran valley, Pakistan. Pak J Bot 2011; 43: 97-103
  • 15 Gilani SS, Abbas SQ, Shinwari ZK, Hussain F, Nargis K. Ethnobotanical studies of Kurram Agency, Pakistan through rural community participation. Pak J Biol Sci 2003; 6: 1368-1375
  • 16 Inouye S, Amano M, Abe S, Amin M, Karim F. Volatile aroma constituents to twenty herbs growing wild in Karakoram/Himalaya in Pakistan (1). Aroma Res 2006; 7: 354-361
  • 17 Inouye S, Uchida K, Abe S. Antimicrobial activity, especially anti-Trichophyton vapor activity of twenty herbs growing wild in the Karakoram (Pakistan Himalayas). Aroma Res 2007; 8: 282-288
  • 18 Hethelyi E, Eseko I, Grosz M, Gergel M, Palinkas J. Capillary GC analysis of Artemisia essential oils. Kozmetika 1995; 44: 117-120
  • 19 Sah S, Lohani H, Narayan O, Bartwal S, Chauhan NK. Volatile constituents of Artemisia maritima Linn. grown in Garhwal Himalaya. J Ess Oil Bear Plants 2010; 13: 603-606
  • 20 Jaitak V, Singh B, Kaul VK. Variability of volatile constituents in Artemisia maritima in western Himalaya. Nat Prod Res 2008; 22: 565-568
  • 21 Sati SC, Sati N, Ahluwalia V, Walia S, Sati OP. Chemical composition and antifungal activity of Artemisia nilagirica essential oil growing in northern hilly areas of India. Nat Prod Res 2013; 27: 45-48
  • 22 Ahameethunisa AR, Hopper W. Antibacterial activity of Artemisia nilagirica leaf extracts against clinical and phytopathogenic bacteria. BMC Complement Alternat Med 2010; 10: 6
  • 23 Cha JD, Jeong MR, Jeong SI, Moon SI, Kim JY, Kil BS, Song YH. Antimicrobial activity of the essential oils of Artemisia scoparia and A. capillaris . Planta Med 2005; 71: 186-190
  • 24 Kazemi M, Dakhili M, Davari M. Constituents and antimicrobial activity of essential oil of Artemisia lehmanniana Bunge from Iran. J Ess Oil Bear Plants 2011; 15: 392-398
  • 25 Kazemi M, Dakhili M, Dadkhah A, Yasrebifar Z, Lafijani K. Composition, antimicrobial and antioxidant activities of the essential oil of Artemisia kermanensis Podl., an endemic species from Iran. J Med Plant Res 2011; 5: 4993-4998
  • 26 Zhang J, Shi B, Gao P, Wang J, Wu W. Composition, in vitro antioxidant and antimicrobial activity of the essential oils from Artemisia lavandulaefolia DC. J Med Plant Res 2012; 6: 1284-1288
  • 27 Tzakou O, Pitarokili D, Chinou IB, Harvala C. Composition and antimicrobial activity of the essential oil of Salvia ringens . Planta Med 2001; 67: 81-83
  • 28 Gupta N, Saxena G, Kalra SS. Antimicrobial activity pattern of certain terpenoids. IJPBS 2011; 2: 87-91
  • 29 Klein G, Rüben C, Upmann M. Antimicrobial activity of essential oil components against potential food spoilage microorganisms. Curr Microbiol 2013; 67: 200-208
  • 30 Panneerselvam C, Murugan K, Kovendan K, Mahesh KP. Mosquito larvicidal, pupicidal, adulticidal and repellent activity of Artemisia nilagirica (Famils: Dompositae) against Anopheles stephensi and Aedes aegypti . Parasitol Res 2012; 111: 2241-2251
  • 31 Wedge DE, Nagle DG. A new 2D-TLC bioautography method for the discovery of novel antifungal agents to control plant pathogens. J Nat Prod 2000; 63: 1050-1054
  • 32 Kumar R, Dubey NK, Tiwari OP, Tripathi YB, Sinha KK. Evaluation of some essential oils as botanical fungitoxicants for the protection of stored food commodities from fungal infestation. J Sci Food Agric 2007; 87: 1737-1742
  • 33 Kumar R, Mishra SK, Dubey NK, Tripathi YB. Evaluation of Chenopodium ambrosioides oil as a potential source of antifungal, antiaflatoxigenic and antioxidant activity. Int J Food Microbiol 2007; 115: 159-164
  • 34 Sharma PK, Raina AP, Dureja P. Evaluation of the antifungal and phytotoxic effects of various essential oils against Sclerotin rolfsii (Sacc) and Rhizoctonia bataticola (Taub). Arch Phytopath Plant Protect 2009; 42: 65-72
  • 35 Singh N, Kaul VK, Megeji NW, Singh V, Shuja PS. Essential oil composition of three accessions of Dracocephalum heterophyllum Benth. cultivated at Palampur, India. NPC 2008; 22: 927-936
  • 36 Schmidt E. Production of essential oils. In: Baser KH, Buchbauer G, editors Handbook of essential oils. Boca Raton: CRC Press; 2010: 89-90
  • 37 Nemeth E, Bernáth J, Tarján G. Quantitative and qualitative studies of essential oils of Hungarian Achillea populations. JHSMP 2007; 13: 57-69
  • 38 Adams RP. Identification of essential oil components by gas chromatography/quadrupole mass spectrometry. Carol Stream: Allured Publishing; 2007
  • 39 Joulain D, Koenig WA. The atlas of spectral data of sesquiterpene hydrocarbons. Hamburg: EB Verlag; 2008
  • 40 Heller SR, Milne GWA. EPA/NIH mass spectral data base. Washington DC: US Government Printing Office; 1978; 1980: 1983
  • 41 Stenhagen E, Abrahamsson S, McLafferty FW. Registry of mass spectral data. New York: Wiley; 1974
  • 42 Swigar AA, Siverstein RM. Monoterpenes. Milwaukee: Aldrich Chemical Co.; 1981
  • 43 Clinical and Laboratory Standards Institute. Method for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; CLSI approved standard document M7-A7, 7th edition. Wayne: CLSI; 2006
  • 44 Clinical and Laboratory Standards Institute. Reference method for broth dilution antifungal susceptibility testing of yeasts: CLSI approved standard M27-A3. 3rd. edition. Wayne: CLSI; 2008
  • 45 Smith BJ, Black LL. Morphological, cultural, and pathogenic variation among Colletotrichum species isolated from strawberry. Plant Dis 1990; 74: 69-76
  • 46 Pridgeon JW, Meepagala KM, Becnel JJ, Clark GG, Pereira RM, Linthicum KJ. Structure-activity relationships of 33 piperidines as toxicants against female adults of Aedes aegypti (Diptera: Culicidae). J Med Entomol 2007; 44: 263-269
  • 47 Klun JA, Kramer M, Debboun M. A new in vitro bioassay system for discovery of novel human-use mosquito repellents. J Am Mosq Control Assoc 2005; 21: 64-70
  • 48 Ali A, Cantrell CL, Bernier UR, Duke SO, Schneider JC, Khan I. Aedes aegypti (Diptera: Culicidae) biting deterrence: structure-activity relationship of saturated and unsaturated fatty acids. J Med Entomol 2012; 49: 1370-1378
  • 49 Pridgeon JW, Becnel JJ, Clark GG, Linthicum KJ. A high throughput screening method to identify potential pesticides for mosquito control. J Med Entomol 2009; 46: 335-341