Planta Med 2014; 80(17): 1605-1614
DOI: 10.1055/s-0034-1383192
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Sucrose Esters from Physalis peruviana Calyces with Anti-Inflammatory Activity

Luis A. Franco
1   Biological Evaluation of Promissory Substances Group, Faculty of Pharmaceutical Sciences, University of Cartagena, Cartagena, Colombia
,
Yanet C. Ocampo
1   Biological Evaluation of Promissory Substances Group, Faculty of Pharmaceutical Sciences, University of Cartagena, Cartagena, Colombia
,
Harold A. Gómez
1   Biological Evaluation of Promissory Substances Group, Faculty of Pharmaceutical Sciences, University of Cartagena, Cartagena, Colombia
,
Rocío De la Puerta
2   Pharmacology Department, Faculty of Pharmacy, University of Seville, Seville, Spain
,
José L. Espartero
3   Organic Chemistry Department, Faculty of Pharmacy, University of Seville, Seville, Spain
,
Luis F. Ospina
4   Pharmacy Department, Faculty of Sciences, National University of Colombia, Bogotá, Colombia
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Publikationsverlauf

received 15. Mai 2014
revised 12. Juli 2014

accepted 18. September 2014

Publikationsdatum:
22. Oktober 2014 (online)

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Abstract

Physalis peruviana is a native plant from the South American Andes and is widely used in traditional Colombian medicine of as an anti-inflammatory medicinal plant, specifically the leaves, calyces, and small stems in poultice form. Previous studies performed by our group on P. peruviana calyces showed potent anti-inflammatory activity in an enriched fraction obtained from an ether total extract. The objective of the present study was to obtain and elucidate the active compounds from this fraction and evaluate their anti-inflammatory activity in vivo and in vitro. The enriched fraction of P. peruviana was purified by several chromatographic methods to obtain an inseparable mixture of two new sucrose esters named peruviose A (1) and peruviose B (2). Structures of the new compounds were elucidated using spectroscopic methods and chemical transformations. The anti-inflammatory activity of the peruvioses mixture was evaluated using λ-carrageenan-induced paw edema in rats and lipopolysaccharide-activated peritoneal macrophages. Results showed that the peruvioses did not produce side effects on the liver and kidneys and significantly attenuated the inflammation induced by λ-carrageenan in a dosage-dependent manner, probably due to an inhibition of nitric oxide and prostaglandin E2, which was demonstrated in vitro. To our knowledge, this is the first report of the presence of sucrose esters in P. peruviana that showed a potent anti-inflammatory effect. These results suggest the potential of sucrose esters from the Physalis genus as a novel natural alternative to treat inflammatory diseases.

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