Subscribe to RSS
DOI: 10.1055/s-0034-1384561
Comparative Study of Three Traditional Mongolian Medicines on Streptozotocin-induced Diabetic Nephropathy in Rats
Publication History
received 26 April 2014
accepted 16 May 2014
Publication Date:
22 July 2014 (online)
Abstract
3 kinds of prescription of Traditional Mongolian (Chinese) Medicine (TMM) have been used in treating diabetic nephropathy (DN). We aimed to investigate: first, which prescription was more effective; second, whether it was more effective when combined with the 3 prescriptions. The DN model was prepared by a single dose of Streptozotocin (STZ, 65 mg/kg, i.p.) in rats and treated 3 times every day with P-1 (Sugmul-10), P-2 (Narenmandul-11), P-3 (Xieriga-4) respectively, and combined group was treated with P-1 in the morning, P-2 and P-3 in the evening. The results showed combining with 3 prescriptions in one day was much more effective than each single prescription. The mechanism of renal protection maybe related to MMP-2 and TGF-β1, the conclusion could be useful and beneficial for clinical medicine.
-
References
- 1 Eckardt KU, Coresh J, Devuyst O et al. Evolving importance of kidney disease: from subspecialty to global health burden. Lancet 2013; 382: 158-169
- 2 Zhao YY. Metabolomics in chronic kidney disease. Clin Chim Acta 2013; 422: 59-69
- 3 Huang C, Shen S, Ma Q et al. Blockade of KCa3.1 ameliorates renal fibrosis through the TGF-β1/Smad pathway in diabetic mice. Diabetes 2013; 62: 2923-2934
- 4 Berthier CC, Zhang H, Schin M et al. Enhanced expression of Janus kinase-signal transducer and activator of transcription path-way members inhuman diabetic nephropathy. Diabetes 2009; 58: 469-477
- 5 Hodgin JB, Nair V, Zhang H et al. Identification of cross-species shared transcriptional networks of diabetic nephropathy in human and mouse glomeruli. Diabetes 2013; 62: 299-308
- 6 Mahnensmith RL, Zorzanello M, Hsu YH et al. A quality improvement model for optimizing care of the diabetic end-stage renal disease patient. Semin Dial 2010; 23: 206-213
- 7 Schulz P. Neurobiology of circadian systems. Dialogues Clin Neurosci 2009; 9: 237-255
- 8 Magalang UJ, Chen NH, Cistulli PA et al. SAGIC Investigators . Agreement in the scoring of respiratory events and sleep among international sleep centers. Sleep 2013; 36: 591-596
- 9 Meolie AL, Rosen C, Kristo D et al. & Clinical Practice Review Committee. Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. Clin Sleep Med 2005; 1: 173-187
- 10 Minami Y, Kasukawa T, Kakazu Y et al. Measurement of internal body time by blood metabolomics. Proc Natl Acad Sci USA 2009; 106: 9890-9895
- 11 Cheng CW, Bian ZX, Wu TX. Systematic review of Chinese herbal medicine for functional constipation. Gastroenterol 2009; 15: 4886-4895
- 12 Litinski M, Scheer FA, Shea SA. Influence of the circadian system on disease severity. Sleep Med Clin 2009; 4: 143-163
- 13 Copinschi G, Spiegel K, Leproult R et al. Pathophysiology of human circadian rhythms. Novartis Found Symp 2000; 227: 143-162
- 14 Wolkow PP, Niewczas MA, Perkins B et al. Association of urinary inflammatory markers and renal decline in microalbuminuric type 1 diabetics. Journal of the American Society of Nephrology 2008; 19: 789-797
- 15 Vergouwe Y, Soedamah-Muthu SS, Zgibor J et al. Progression to microalbuminuria in type 1 diabetes: development and validation of a prediction rule. Diabetologia 2010; 53: 254-262
- 16 Busik JV, Tikhonenko M, Bhatwadekar A et al. Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock. Exp Med 2009; 206: 2897-2906
- 17 Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 2006; 69: 562-573
- 18 Sen U, Rodriguez WE, Tyagi N et al. Ciglitazone, a PPARγ agonist, ameliorates diabetic nephropathy in part through homocysteine clearance. Am Physiol Endocrinol Metab 2008; 295: E1205- E1212
- 19 Baricos WH, Cortez SL, Deboisblanc M et al. Transforming growth factor-β is a potent inhibitor of extracellular matrix degradation by cultured human mesangial cells. Am Soc Nephrol 1999; 10: 790-795
- 20 Wang CY, Wen MS, Wang HW et al. Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2. Circulation 2008; 118: 2166-2173
- 21 Ruiter MR, Buijs M, Kalsbeek A. Hormones and the autonomic nervous system are involved in suprachiasmatic nucleus modulation of glucose homeostasis. Curr Diabetes Rev 2006; 2: 213-226
- 22 Weston PJ, Gill GV. Is undetected autonomic dysfunction responsible for sudden death in type 1 diabetes mellitus? The ‘dead in bed’ syndrome revisited. Diabet Med 1999; 16: 626-631