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DOI: 10.1055/s-0034-1385217
Multigene Assays for Classification, Prognosis, and Prediction in Breast Cancer: a Critical Review on the Background and Clinical Utility
Multigenassays zur Beurteilung der Klassifikation, Prognose und Prädiktion beim Mammakarzinom. Ein kritischer Review zum Hintergrund und klinischen NutzenPublikationsverlauf
Publikationsdatum:
07. Oktober 2014 (online)
![](https://www.thieme-connect.de/media/senologie/201403/lookinside/thumbnails/10.1055-s-0034-1385217-1.jpg)
Abstract
Gene signatures which are based on multigene profiling assays have been developed for the purpose to better define the prognosis and prediction of therapy results in early-stage breast cancer. These assays were designed to be more specific than conventional clinico-pathologic parameters in the selection of patients for (neo-)adjuvant treatment and in effect help to avoid unnecessary cytotoxic treatment. In this review we describe molecular risk scores, for which tests are commercially available (PAM50®, MammaTyper®, MammaPrint®, Oncotype DX®, Endopredict®, Genomic Grade Index®) and IHC risk scores (Mammostrat® and IHC4), and discuss the current evidence of their clinical use.
Zusammenfassung
In den letzten Jahren wurden eine Reihe verschiedener Gensignaturen, die auf Multigenassays basieren, für die Abschätzung der Prognose und Prädiktion beim frühen Mammakarzinom entwickelt. Die Zielsetzung dieser Assays ist die Verbesserung der Spezifität gegenüber konventionellen klinisch-pathologischen Parametern für die Therapieplanung, speziell für die Optimierung der Selektion von Patienten für die (neo-)adjuvante Therapie und zur Vermeidung überflüssiger zytotoxischer Therapien. In diesem Review beschreiben wir wichtige molekulare Risikoscores, für die Tests kommerziell angeboten werden (PAM50®, MammaTyper®, MammaPrint®, Oncotype DX®, Endopredict®, Genomic Grade Index®), sowie vergleichbare immunhistochemische (IHC) Risikoscores (Mammostrat®, IHC4), und diskutieren die wissenschaftliche Evidenz dieser Tests und deren klinischen Anwendungsbereich.
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