Onset of Exercise and Diet Program in Obese Women: Metabolic and Anorexigenic Responses Related to Weight Loss and Physical Capacities

F. D. Desgorces; C. Le Page; C. Police; N. Neveux; C. H. Cottart; M. C. Blanc; J. Raison; J. F. Toussaint; P. Noirez

doi:10.1055/s-0034-1387704

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2015; 47(07): 473-478
DOI: 10.1055/s-0034-1387704

Endocrine Care

Onset of Exercise and Diet Program in Obese Women: Metabolic and Anorexigenic Responses Related to Weight Loss and Physical Capacities

Authors

F. D. Desgorces

¹Université Paris Descartes, Sorbonne Paris Cité, Paris, France

²IRMES, EA 7329 Université Paris Descartes, INSEP, Paris, France

³UFR STAPS, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
C. Le Page

¹Université Paris Descartes, Sorbonne Paris Cité, Paris, France

³UFR STAPS, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

⁴UBIAE, INSERM U902, Université Evry-Val d’Essonne, Evry, France
C. Police

¹Université Paris Descartes, Sorbonne Paris Cité, Paris, France

³UFR STAPS, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
N. Neveux

¹Université Paris Descartes, Sorbonne Paris Cité, Paris, France

⁵Centre d’Investigation en médecine du Sport, Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France

⁶Service de Biochimie, Groupe hospitalier Broca-Cochin-Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France
C. H. Cottart

¹Université Paris Descartes, Sorbonne Paris Cité, Paris, France

⁵Centre d’Investigation en médecine du Sport, Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France

⁷Service de Biochimie, Groupe hospitalier Necker Enfants-Malades, Assistance Publique-Hôpitaux de Paris, Paris, France
M. C. Blanc

¹Université Paris Descartes, Sorbonne Paris Cité, Paris, France

⁵Centre d’Investigation en médecine du Sport, Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France

⁶Service de Biochimie, Groupe hospitalier Broca-Cochin-Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France
J. Raison

⁸Hôpital Manhes, Fleury-Mérogis, France
J. F. Toussaint

¹Université Paris Descartes, Sorbonne Paris Cité, Paris, France

²IRMES, EA 7329 Université Paris Descartes, INSEP, Paris, France

⁹EA 4466, Faculté de Pharmacie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
P. Noirez

¹Université Paris Descartes, Sorbonne Paris Cité, Paris, France

²IRMES, EA 7329 Université Paris Descartes, INSEP, Paris, France

³UFR STAPS, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

⁵Centre d’Investigation en médecine du Sport, Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France

Abstract

Perturbations of energy balance induce compensatory processes that may alter expected weight loss. In obese patients, our aim was to investigate the relationships that occurred between fasting plasma concentrations of anorexigenic peptides and metabolic parameters, appetite, physical capacity, and weight loss in the 5 first days of a program associating exercise and caloric reduction. Thirteen obese women were monitored from day 1 to day 5 with 2 exercise sessions in day 2 and day 4. We measured, in a fasted state, changes in body weight, hunger ratings, and plasma concentrations of fatty acids, triglycerides, leptin, insulin, amylin, peptide YY, and insulin-resistance index. Physical performance was assessed by a 6-min walking test. The program resulted in significantly reduced body weight (0.75±0.4 kg; p=0.001), of plasma concentrations of triglycerides, insulin, amylin, peptide YY, and the insulin-resistance index, and also increased fatty acids (p<0.05). Hunger ratings were increased (p<0.05). Program-induced changes in fatty acids, leptin, and insulin concentrations were related to physical performance (r²=0.45, 0.59, and 0.52; p<0.05, respectively) and to weight loss (r²=0.65, 0.57, 0.55; p<0.05, respectively). Five days of diet and exercise induced weight loss, improved lipid profile, and decreased insulin resistance while hunger ratings increased. Subjects with higher physical capacity lost more weight, presented higher increases in fatty acids and lower changes of leptin and insulin concentrations suggesting a better metabolic flexibility. To reduce the compensatory responses that can occur with energy imbalances, our study supports to account for individual activity level before prescribing weight-loss program associating diet and exercise.

Key words

body weight - leptin - insulin resistance - exercise - nutrition

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