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DOI: 10.1055/s-0034-1387756
Antiatherosclerotic Potential of Rhizoma Polygonati Polysaccharide in Hyperlipidemia-induced Atherosclerotic Hamsters
Publication History
received 25 September 2013
accepted 06 August 2014
Publication Date:
10 September 2014 (online)
![](https://www.thieme-connect.de/media/drugres/201509/lookinside/thumbnails/2013-09-0423_10-1055-s-0034-1387756-1.jpg)
Abstract
The present study aimed to investigate the antiatherosclerotic effect of rhizoma polygonati polysaccharide. Adult golden hamsters (Mesocricetus auratus) were fed an atherosclerotic diet containing 1.5 mL olive oil, 8 mg (320 000 IU) vitamin D2, and 40 mg cholesterol for 60 consecutive days to induce atherosclerosis. These hamsters then orally received either the reference drug simvastatin (5 mg/kg) or rhizoma polygonati polysaccharide (0.57 g/kg or 1.14 g/kg) once daily for 60 additional days before comparison to normal and atherosclerotic controls. Treatment with rhizoma polygonati polysaccharide resulted in significant improvement (p<0.01) in serum lipid profile, apolipoproteins, and endothelial dysfunction parameters. Histomorphological studies confirmed biochemical findings. The results showed that rhizoma polygonati polysaccharide has a protective effect against hyperlipidemia-induced atherosclerosis in hamsters.
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